TASSEL: software for association mapping of complex traits in diverse samples
TASSEL: software for association mapping of complex traits in diverse samples
复制标题
DOI：
10.1093/bioinformatics/btm308
复制
发表时间：
2007-10-01
期刊：
影响因子：
5.8
通讯作者：
Buckler, Edward S.
中科院分区：
文献类型：
--
作者：
Bradbury, Peter J.;Zhang, Zhiwu;Buckler, Edward S.
利用基因组的自然多样性以非常高的分辨率绘制图谱的关联分析正变得越来越重要。然而，在大多数研究中，研究人员必须与人口和家庭结构的混杂效应作斗争。TASSEL（Trait Analysis by aSSociation，Evolution and Linkage）采用一般线性模型和混合线性模型方法控制群体和家庭结构。对于结果解释，该程序允许连锁不平衡统计数据进行计算和可视化图形。通过集成中间件实现数据库浏览和数据导入。其他功能包括分析插入/缺失，计算多样性统计，整合表型和基因型数据，插补缺失数据和计算主成分。
Association analyses that exploit the natural diversity of a genome to map at very high resolutions are becoming increasingly important. In most studies, however, researchers must contend with the confounding effects of both population and family structure. TASSEL (Trait Analysis by aSSociation, Evolution and Linkage) implements general linear model and mixed linear model approaches for controlling population and family structure. For result interpretation, the program allows for linkage disequilibrium statistics to be calculated and visualized graphically. Database browsing and data importation is facilitated by integrated middle-ware. Other features include analyzing insertions/deletions, calculating diversity statistics, integration of phenotypic and genotypic data, imputing missing data and calculating principal components.