Wood dust exposure and the association with lung cancer risk
Wood dust exposure and the association with lung cancer risk
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DOI：
10.1002/ajim.20137
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发表时间：
2005-04-01
影响因子：
3.5
通讯作者：
Spitz, MR
中科院分区：
文献类型：
--
作者：
Barcenas, CH;Delclos, GL;Spitz, MR
Background Wood dust was designated as a human carcinogen based on increased sinus and nasal cancer rates among exposed workers. However, data on an association with lung cancer have been inconclusive.Methods Self-reported wood dust exposure was compared between 1,368 lung cancer patients and 1,192 cancer-free adults, in a lung cancer case-control study. Epidemiological information was collected through a detailed personal interview.Results Using several definitions of wood dust exposure we consistently observed statistically significant elevated adjusted risk estimates; for example, the adjusted odds ratio (OR) for combined wood dust related occupations and industries was 3.15 (95% confidence intervals (CI) 1.45-6.86) and for an overall summary exposure measure it was 1.60 (95% CI 1. 19-2.14). The association was maintained when stratified by histopathological type. Among those exposed to cigarette smoke and wood dust, 21% of the cases were attributable to biologic interaction.Conclusions Wood dust exposure is a potential risk factor for lung cancer Am. J. Ind. Med. 47:349-357, 2005. (c) 2005 Wiley-Liss, Inc.
