Maternal Serum 25-Hydroxyvitamin D Concentrations Are Associated with Small-for-Gestational Age Births in White Women
Maternal Serum 25-Hydroxyvitamin D Concentrations Are Associated with Small-for-Gestational Age Births in White Women
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DOI：
10.3945/jn.109.119636
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发表时间：
2010-05-01
影响因子：
4.2
通讯作者：
Simhan, Hyagriv N.
中科院分区：
文献类型：
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作者：
Bodnar, Lisa M.;Catov, Janet M.;Simhan, Hyagriv N.
母亲维生素D缺乏与许多不利的健康后果有关，但它与胎儿生长受限的关系仍不确定。我们试图阐明妊娠早期孕妇血清25-羟基维生素D[25(OH)D]浓度与小于胎龄出生(SGA)风险的关系，并探讨母亲维生素D受体(VDR)基因单核苷酸多态性(SNP)与SGA风险的关系。我们对分娩SGA婴儿(白人77例，黑人34例)和非SGA婴儿(白人196例，黑人105例)的未分娩单胎妊娠妇女进行了嵌套式病例对照研究。妇女们被跟踪从
Maternal vitamin D deficiency has been associated with numerous adverse health outcomes, but its association with fetal growth restriction remains uncertain. We sought to elucidate the association between maternal serum 25-hydroxyvitamin D [25(OH)D] concentrations in early pregnancy and the risk of small-for-gestational age birth (SGA) and explore the association between maternal single nucleotide polymorphisms (SNP) in the vitamin D receptor (VDR) gene and the risk of SGA. We conducted a nested case-control study of nulliparous pregnant women with singleton pregnancies who delivered SGA infants (n = 77 white and n = 34 black) or non-SGA infants (n = 196 white and n = 105 black). Women were followed from