Klinefelter syndrome and risk of psychosis, autism and ADHD
Klinefelter syndrome and risk of psychosis, autism and ADHD
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DOI：
10.1016/j.jpsychires.2013.10.001
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发表时间：
2014-01-01
影响因子：
4.8
通讯作者：
Lichtenstein, Paul
中科院分区：
文献类型：
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作者：
Cederlof, Martin;Gotby, Agnes Ohlsson;Lichtenstein, Paul
背景：精神分裂症、双相情感障碍、自闭症谱系障碍和多动症可能在Klinefelter综合征中被过度代表，但之前的调查没有得出决定性的结果。方法：我们比较了瑞典860例克氏综合征患者和86000例匹配人群对照。为了评估Klinefelter患者患精神分裂症、双相情感障碍、自闭症谱系障碍和多动症的风险，我们使用条件logistic回归估计了比值比和95%置信区间。结果：Klinefelter患者患精神分裂症(OR) = 3.6, 95%可信区间（CI） 2.0 ~ 6.7，双相情感障碍（OR = 3.8, CI 1.8 ~ 7.6）的风险高出近4倍，患自闭症谱系障碍（OR = 6.2, CI 4.0 ~ 9.4）和多动症（OR = 5.6, CI 4.0 ~ 7.8）风险高出约6倍。结论：Klinefelter患者出现精神病、自闭症和ADHD的风险增加。这些发现表明，在所研究的精神疾病的病因学中存在X染色体相关因素，并且可能对Klinefelter综合征患者的治疗也有影响。(C) 2013 Elsevier Ltd.版权所有。
Background: Schizophrenia, bipolar disorder, autism spectrum disorders and ADHD might be over-represented in Klinefelter syndrome, but previous investigations have yielded inconclusive results.Methods: We compared a national sample of 860 Klinefelter patients in Sweden with 86 000 matched population controls. To assess the risks of schizophrenia, bipolar disorder, autism spectrum disorder and ADHD in Klinefelter patients, we estimated odds ratios and 95% confidence intervals using conditional logistic regressions.Results: Klinefelter patients had almost four times higher risks of schizophrenia, odds ratio (OR) = 3.6, 95% confidence interval (CI) 2.0-6.7 and bipolar disorder (OR = 3.8, CI 1.8-7.6) and about six times higher risk of autism spectrum disorder (OR = 6.2, Cl 4.0-9.4) and ADHD (OR = 5.6, CI 4.0-7.8).Conclusions: The risk of psychosis, autism and ADHD is increased in Klinefelter patients. These findings indicate an X chromosome-related factor in the etiology of the studied psychiatric disorders, and may also have implications for treatment of patients with Klinefelter syndrome. (C) 2013 Elsevier Ltd. All rights reserved.