Sensory neurons control the functions of dendritic cells to guide allergic immunity.
Sensory neurons control the functions of dendritic cells to guide allergic immunity.
复制标题
感觉神经元控制树突状细胞的功能以指导过敏性免疫。
DOI：
10.1016/j.coi.2021.10.009
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发表时间：
2022-03
影响因子：
7
通讯作者：
Sokol CL
中科院分区：
文献类型：
--
作者：
Flayer CH;Sokol CL
先天免疫系统的树突状细胞和周围神经系统的感觉神经元嵌入在屏障组织中，收集生物体环境的信息。虽然树突状细胞识别和启动对病原体的适应性免疫反应的机制已经很好地定义，但它们如何感知过敏原却知之甚少。事实上，过敏原在体内诱导树突状细胞成熟和迁移，但在体外却没有。如果树突状细胞不直接感知过敏原，如何启动对过敏原的适应性免疫反应？感觉神经元在接触过敏原几分钟内释放神经肽。最近的证据表明，虽然神经肽在病原体反应中改变树突细胞的功能，但它们是过敏反应中树突细胞功能所必需的。这些新出现的研究表明，感觉神经元不仅向中枢神经系统传递信息，还向树突状细胞传递信息，特别是在对过敏原产生适应性免疫的过程中。
Dendritic cells of the innate immune system and sensory neurons of the peripheral nervous system are embedded in barrier tissues and gather information about an organisms’ environment. While the mechanisms by which dendritic cells recognize and initiate adaptive immune responses to pathogens is well defined, how they sense allergens is poorly understood. Indeed, allergens induce dendritic cell maturation and migration in vivo, but not in vitro. How are adaptive immune responses to allergens initiated if dendritic cells do not directly sense allergens? Sensory neurons release neuropeptides within minutes of allergen exposure. Recent evidence demonstrated that while neuropeptides modify dendritic cell function during pathogen responses, they are required for dendritic cell function during allergic responses. These emerging studies suggest that sensory neurons do not just pass information along to the central nervous system, but also to dendritic cells, particularly during the initiation of adaptive immunity to allergens.
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影响因子：
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