Methylene blue and Alzheimer's disease
Methylene blue and Alzheimer's disease
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DOI：
10.1016/j.bcp.2009.04.034
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发表时间：
2009-10-15
影响因子：
5.8
通讯作者：
Petroianu, George A.
中科院分区：
文献类型：
--
作者：
Oz, Murat;Lorke, Dietrich E.;Petroianu, George A.
亚甲基蓝（MB）和阿尔茨海默病（AD）之间的关系最近引起了越来越多的科学关注，因为它已被建议，MB可能会减缓这种疾病的进展。事实上，MO除了对cGMP通路的充分表征的抑制作用外，还影响许多与AD进展密切相关的细胞和分子事件。目前，MB已被证明可以减弱淀粉样蛋白斑块和神经纤维缠结的形成，并部分修复线粒体功能和细胞代谢的损伤。此外，被认为在AD和其他认知障碍的发病机制中起重要作用的各种神经递质系统（胆碱能、胆碱能和多巴胺能）也受到MB的影响。最近的研究表明，MB对这些细胞功能的不同作用的组合可能介导MB的潜在有益作用。这导致了开发用于AD的新的基于MB的治疗方式的尝试。在这篇综述文章中，MB对神经递质系统和多个细胞和分子靶点的作用总结了它们与AD的相关性。(C)2009爱思唯尔公司All rights reserved.
The relationship between methylene blue (MB) and Alzheimer's disease (AD) has recently attracted increasing scientific attention since it has been suggested that MB may slow down the progression of this disease. In fact, MO, in addition to its well characterized inhibitory actions on the cGMP pathway, affects numerous cellular and molecular events closely related to the progression of AD. Currently, MB has been shown to attenuate the formations of amyloid plaques and neurofibrillary tangles, and to partially repair impairments in mitochondrial function and cellular metabolism. Furthermore, various neurotransmitter systems (cholinergic, serotonergic and glutamatergic), believed to play important roles in the pathogenesis of AD and other cognitive disorders, are also influenced by MB. Recent studies suggest that the combination of diverse actions of MB on these cellular functions is likely to mediate potential beneficial effects of MB. This has lead to attempts to develop novel MB-based treatment modalities for AD. In this review article, actions of MB on neurotransmitter systems and multiple cellular and molecular targets are summarized with regard to their relevance to AD. (C) 2009 Elsevier Inc. All rights reserved.