INHIBITORY EFFECTS OF THE PINEAL HORMONE MELATONIN AND UNDERFEEDING DURING THE PROMOTIONAL PHASE OF 7,12-DIMETHYLBENZANTHRACENE-(DMBA)-INDUCED MAMMARY TUMORIGENESIS
INHIBITORY EFFECTS OF THE PINEAL HORMONE MELATONIN AND UNDERFEEDING DURING THE PROMOTIONAL PHASE OF 7,12-DIMETHYLBENZANTHRACENE-(DMBA)-INDUCED MAMMARY TUMORIGENESIS
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DOI：
10.1007/bf01243365
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发表时间：
1986-01-01
影响因子：
3.3
通讯作者：
MASSA, JS
中科院分区：
文献类型：
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作者：
BLASK, DE;HILL, SM;MASSA, JS
在雌性Sprague-Dawley大鼠中研究了褪黑激素（Mel）和/或喂养不足（30%食物限制）对7，12-二甲基苯并蒽（DMBA）诱导的乳腺肿瘤发生的影响。在肿瘤发生的促进阶段，动物开始每天下午接受Mel（250 μ g）或盐水载体皮下注射。15周与进食动物相比，进食不足的大鼠具有较低的肿瘤发生率、肿瘤数量和大小，而肿瘤发病和消退的潜伏期增加。褪黑激素在喂养大鼠中适度抑制肿瘤发生率和数量。然而，Mel处理和喂养不足的组合与单独的处理相比引起了最显著的肿瘤发生抑制。这些结果表明，Mel管理和/或喂养不足，在促进阶段抑制DMBA诱导的乳腺肿瘤发生可能通过神经内分泌和/或外周内分泌机制。
The effects of melatonin (Mel) and/or underfeeding (30% food restriction) on 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumorigenesis were examined in female Sprague-Dawley rats fed a semipurified diet. During the promotional phase of tumorigenesis, the animals began receiving either daily afternoon Mel (250.mu.g) or saline vehicle injections s.c. for 15 weeks. As compared with fed animals, underfed rats had a lower tumor incidence, tumor number and size while the latency to onset and regression of tumors was increased. Melatonin in fed rats moderately suppressed tumor incidence and number. However, the combination of Mel treatment and underfeeding caused the most marked inhibition of tumorigenesis as compared with either treatment alone. These results indicate that Mel administration and/or underfeeding during the promotional phase inhibit DMBA-induced mammary tumorigenesis perhaps via neuroendocrine and/or peripheral endocrine mechanisms.