The SarA protein family of Staphylococcus aureus
The SarA protein family of Staphylococcus aureus
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DOI：
10.1016/j.biocel.2007.10.032
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发表时间：
2008-01-01
影响因子：
4
通讯作者：
Tamber, Sandeep
中科院分区：
文献类型：
--
作者：
Cheung, Ambrose L.;Nishina, Koren A.;Tamber, Sandeep
金黄色葡萄球菌被广泛认为是一种机会致病菌，主要发生在医院相关感染中。然而，最近的报告表明，S。金黄色葡萄球菌感染现在可以发生在社区环境中的其他健康个体中。这种生物的成功可以归因于大量的调节蛋白，包括SarA蛋白家族，用于响应不断变化的微环境。序列比对和结构分析表明，SarA蛋白家族可分为三个亚家族：（1）单结构域蛋白;（2）双结构域蛋白;（3）马尔R同源蛋白。结构研究还表明，SarA，SarR，SarS，MgrA，因此可能所有成员的这个蛋白质家族是有翼螺旋蛋白与微小的变化。突变研究表明，SarA的翼螺旋基序对DNA结合和功能非常重要。最新进展有关的功能和合理的机制的调节SarA及其同系物进行了讨论。(c)2007爱思唯尔有限公司版权所有。
Staphylococcus aureus is widely appreciated as an opportunistic pathogen, primarily in hospital-related infections. However, recent reports indicate that S. aureus infections can now occur in other wise healthy individuals in the community setting. The success of this organism can be attributed to the large array of regulatory proteins, including the SarA protein family, used to respond to changing microenvironments. Sequence alignment and structural data reveal that the SarA protein family can be divided into three subfamilies: (1) single domain proteins; (2) double domain proteins; (3) MarR homologs. Structural studies have also demonstrated that SarA, SarR, SarS, MgrA and thus possibly all members of this protein family are winged helix proteins with minor variations. Mutagenesis studies of SarA disclose that the winged helix motifs are important for DNA binding and function. Recent progress concerning the functions and plausible mechanisms of regulation of SarA and its homologs are discussed. (c) 2007 Elsevier Ltd. All rights reserved.