Perfusion cells for studying regional variation in oral mucosal permeability in humans. 2. A specialized transport mechanism in D-glucose absorption exists in dorsum of tongue
Perfusion cells for studying regional variation in oral mucosal permeability in humans. 2. A specialized transport mechanism in D-glucose absorption exists in dorsum of tongue
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DOI：
10.1021/js9703028
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发表时间：
1998-05-01
影响因子：
3.8
通讯作者：
Kimura, T
中科院分区：
文献类型：
--
作者：
Kurosaki, Y;Yano, K;Kimura, T
为了明确人体口腔中D-葡萄糖吸收的部位，将新设计的灌注细胞应用于人体口腔的五个不同部位，即舌背、舌腹面、唇粘膜、口底和颊粘膜。将D-葡萄糖溶液灌注1小时，并根据从灌注液中消失的量计算吸收率。 D-葡萄糖从舌背吸收迅速，且吸收饱和。在舌头的腹侧表面也观察到了饱和吸收，但在其他三个部位没有观察到。舌背和腹面D-葡萄糖吸收率显着大于L-葡萄糖，而其他部位无显着差异。有人提出，人类舌背存在一种专门吸收 D-葡萄糖的运输系统。
To clarify the site of D-glucose absorption in human oral cavity, newly designed perfusion cells were applied to five different sites in the human oral cavity, i.e., the dorsum of the tongue, the ventral surface of the tongue, the labial mucosa, the floor of the mouth, and the buccal mucosa. The solution of D-glucose was perifused for 1 h and the rate of absorption was calculated from the amount that disappeared from the perfusate. D-Glucose was absorbed rapidly from the dorsum of the tongue and the absorption was saturable. The saturable absorption was also observed in the ventral surface of the tongue, but not in the other three sites. The rate of D-glucose absorption in the dorsum and the ventral surface of the tongue was significantly larger than that of L-glucose, while in the other sites they were not significantly different. The presence of a specialized transport system for D-glucose absorption in the dorsum of human tongue was suggested.