Partitioning of Cell Surface Class II Expression and Antigen Presenting Capacity of Macrophages in An MHC-GENE Dosage Model

Partitioning of Cell Surface Class II Expression and Antigen Presenting Capacity of Macrophages in An MHC-GENE Dosage Model
复制标题

MHC-GENE 剂量模型中细胞表面 II 类表达的划分和巨噬细胞的抗原呈递能力

DOI:
10.1080/10495399109525754
复制
发表时间:
1991
影响因子:
3.7
通讯作者:
R. Dietert
R. Dietert
中科院分区:
农林科学4区
文献类型:
--
作者:
H.‐K. Lin;S. Bloom;R. Dietert

文献摘要

参考文献

被引文献

相似文献

摘要抗原提呈需要细胞内处理外源抗原,以产生在主要组织相容性复合体(MHC)II类分子的背景下在抗原提呈细胞(APC)表面展示的免疫原性肽。我们比较了葡聚糖凝胶诱导的含有编码MHC的微染色体的两个(二体)、三个(三体)或四个(四体)拷贝的鸡腹腔巨噬细胞的MHC II类抗原的定量细胞表面表达和抗原呈递能力。使用间接免疫荧光流式细胞术,与腹膜内(i. p.)葡聚糖凝胶注射液。在Sephadex后42小时,来自二体和非整倍体(三体和四体)鸡的腹膜渗出液细胞(佩奇)在II类阳性细胞的发生率方面相似;然而,...
Abstract Antigen presentation requires intracellular processing of foreign antigens to generate immunogenic peptides displayed at the surface of antigen presenting cells (APCs) in the context of major histocompatibility complex (MHC) class II molecules. We compared Sephadex‐elicited chicken peritoneal macrophages containing either two (disomic), three (trisomic), or four (tetrasomic) copies of the microchromosome encoding the MHC for both quantitative cell surface expression of MHC class II antigens and antigen presentation ability. Using indirect immunofluorescence flow cytometry, an increased percentage of class II‐positive cells and elevated mean class II‐related fluorescence intensity was found among tetrasomic macrophages as compared to disomic controls harvested 4 hours after intraperitoneal (i.p.) Sephadex injection. At 42 hr post Sephadex, peritoneal exudate cells (PECs) from disomic and aneuploid (trisomic and tetrasomic) chickens were similar in the incidence of class II‐positive cells; however,...
粒细胞-巨噬细胞集落刺激因子或巨噬细胞集落刺激因子培养的骨髓细胞来源的巨噬细胞中 Ia 抗原表达的分析。
DOI: --
发表时间: 1988
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Falk,LA;Wahl,LM;Vogel,SN
通讯作者: Vogel,SN
TPA(12-O-十四烷酰基-佛波醇-13-乙酸酯)激活和分化人外周 B 淋巴细胞。
DOI: --
发表时间: 1984
期刊: Immunology
影响因子: 6.4
作者:
Aman,P;Gordon,J;Klein,G
通讯作者: Klein,G
内源性花生四烯酸代谢物体外调节巨噬细胞 Ia 表达的功能意义。
DOI: --
发表时间: 1986
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Tripp,CS;Wyche,A;Unanue,ER;Needleman,P
通讯作者: Needleman,P
MHC 染色体剂量对胚胎和新生鸡法氏囊 B 细胞亚群的影响。
DOI: 10.1016/0145-305x(92)90006-x
发表时间: 1992
影响因子: 2.9
作者:
Delany,ME;Dietert,RR;Bloom,SE
通讯作者: Bloom,SE
DOI: --
发表时间: 1985
期刊: The Journal of heredity
影响因子: --
作者:
Bloom,SE;Bacon,LD
通讯作者: Bacon,LD