Partitioning of Cell Surface Class II Expression and Antigen Presenting Capacity of Macrophages in An MHC-GENE Dosage Model
Partitioning of Cell Surface Class II Expression and Antigen Presenting Capacity of Macrophages in An MHC-GENE Dosage Model
复制标题
MHC-GENE 剂量模型中细胞表面 II 类表达的划分和巨噬细胞的抗原呈递能力
DOI:
10.1080/10495399109525754
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发表时间:
1991
影响因子:
3.7
通讯作者:
R. Dietert
中科院分区:
文献类型:
--
作者:
H.‐K. Lin;S. Bloom;R. Dietert
Abstract Antigen presentation requires intracellular processing of foreign antigens to generate immunogenic peptides displayed at the surface of antigen presenting cells (APCs) in the context of major histocompatibility complex (MHC) class II molecules. We compared Sephadex‐elicited chicken peritoneal macrophages containing either two (disomic), three (trisomic), or four (tetrasomic) copies of the microchromosome encoding the MHC for both quantitative cell surface expression of MHC class II antigens and antigen presentation ability. Using indirect immunofluorescence flow cytometry, an increased percentage of class II‐positive cells and elevated mean class II‐related fluorescence intensity was found among tetrasomic macrophages as compared to disomic controls harvested 4 hours after intraperitoneal (i.p.) Sephadex injection. At 42 hr post Sephadex, peritoneal exudate cells (PECs) from disomic and aneuploid (trisomic and tetrasomic) chickens were similar in the incidence of class II‐positive cells; however,...
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DOI:
--
发表时间:
1988
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Falk,LA;Wahl,LM;Vogel,SN
通讯作者:
Vogel,SN
影响因子:
6.4
作者:
Aman,P;Gordon,J;Klein,G
通讯作者:
Klein,G
DOI:
--
发表时间:
1986
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Tripp,CS;Wyche,A;Unanue,ER;Needleman,P
通讯作者:
Needleman,P
影响因子:
2.9
作者:
Delany,ME;Dietert,RR;Bloom,SE
通讯作者:
Bloom,SE
DOI:
--
发表时间:
1985
期刊:
The Journal of heredity
影响因子:
--
作者:
Bloom,SE;Bacon,LD
通讯作者:
Bacon,LD