Hyperpolarized nanodiamond with long spin-relaxation times.
Hyperpolarized nanodiamond with long spin-relaxation times.
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DOI：
10.1038/ncomms9459
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发表时间：
2015-10-09
影响因子：
16.6
通讯作者：
Reilly DJ
中科院分区：
文献类型：
--
作者：
Rej E;Gaebel T;Boele T;Waddington DE;Reilly DJ
在磁共振中使用超极化试剂（例如 13C 标记化合物）可实现强大的新成像和检测模式，信号增强 10,000 倍。超极化技术未来的一个主要挑战是固有的短自旋弛豫时间，对于 13C 液态化合物来说通常<60秒，这限制了信号保持增强的时间。在这里，我们证明了合成纳米金刚石中 1.1% 自然丰度的 13C 自旋可以在低温和室温下超极化，而无需使用自由基，并且由于其固态环境，表现出超过 1 小时的弛豫时间。结合纳米金刚石在生命科学中作为廉价荧光标记物和用于基因和药物输送的非细胞毒性底物的已经确立的应用，这些结果将纳米级金刚石的治疗诊断能力扩展到超极化磁共振领域。 超极化碳核是用于磁共振成像的有前途的造影剂，但通常具有低于一分钟的弛豫时间。在这里，作者证明了合成纳米金刚石中 13C 的低温和室温超极化，弛豫时间超过一小时。
The use of hyperpolarized agents in magnetic resonance, such as 13C-labelled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarization technique is the inherently short spin-relaxation times, typically <60 s for 13C liquid-state compounds, which limit the time that the signal remains boosted. Here we demonstrate that 1.1% natural abundance 13C spins in synthetic nanodiamond can be hyperpolarized at cryogenic and room temperature without the use of free radicals, and, owing to their solid-state environment, exhibit relaxation times exceeding 1 h. Combined with the already established applications of nanodiamonds in the life sciences as inexpensive fluorescent markers and non-cytotoxic substrates for gene and drug delivery, these results extend the theranostic capabilities of nanoscale diamonds into the domain of hyperpolarized magnetic resonance. Hyperpolarized carbon nuclei are promising contrast agents for magnetic resonance imaging, but typically possess relaxation times below one minute. Here, the authors demonstrate cryogenic and room temperature hyperpolarization of 13C in synthetic nanodiamonds with relaxation times exceeding one hour.