Nickel-Catalyzed Highly Regio- and Stereoselective Cross-Trimerization between Triisopropylsilylacetylene and Internal Alkynes Leading to 1,3-Diene-5-ynes
Nickel-Catalyzed Highly Regio- and Stereoselective Cross-Trimerization between Triisopropylsilylacetylene and Internal Alkynes Leading to 1,3-Diene-5-ynes
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DOI：
10.1021/ja900146u
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发表时间：
2009-03-11
影响因子：
15
通讯作者：
Fukuzawa, Shin-ichi
中科院分区：
文献类型：
--
作者：
Ogata, Kenichi;Murayama, Hiroyuki;Fukuzawa, Shin-ichi
使用 Ni(cod)(2)/(PPr3)-Pr-n 催化剂实现了三异丙基甲硅烷基乙炔和 2 当量内炔之间的首次高选择性 1:2 交叉三聚，生成 1,3-二烯-5-炔化合物。各种对称和不对称的内部炔烃可用于具有高区域和立体选择性的交叉三聚反应。
The first highly selective 1:2 cross-trimerization between triisopropylsilytacetylene and 2 equiv of internal alkynes, leading to 1,3-diene-5-yne compounds, was achieved using the Ni(cod)(2)/(PPr3)-Pr-n catalyst. Various symmetrical and asymmetrical internal alkynes could be used for the cross-trimerization reaction with high regio- and stereoselectivity.