Effector memory CD8+ T cells are resistant to apoptosis
Effector memory CD8+ T cells are resistant to apoptosis
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DOI：
10.1196/annals.1398.017
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Gollapudi, Sastry
中科院分区：
文献类型：
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作者：
Gupta, Sudhir;Gollapudi, Sastry
Based upon their migrating properties and effector functions, CD8(+) T cells have been further classified into central memory (T-CM) and two types of effector memory (T-EM and T-EMRA) cells. These memory cells display distinct replicative characteristics. Because apoptosis plays an important role in cellular homeostasis, we have examined the relative sensitivity of naive (T-N) and different memory CD8+ T cells to apoptosis. We show that both T-EM and T-EMRA CD8+ T cells are resistant to apoptosis, whereas T-N and T-CM CD8(+) T cells are sensitive to apoptosis.
