Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION).
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION).
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DOI：
10.3402/nano.v1i0.5358
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Doak SH
中科院分区：
文献类型：
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作者：
Singh N;Jenkins GJ;Asadi R;Doak SH
超顺磁性氧化铁纳米粒子（SPION）广泛用于各种生物医学应用，例如磁共振成像、药物或基因的靶向递送以及热疗。尽管 SPION 的潜在好处相当大，但仍迫切需要识别与这些纳米粒子相关的任何潜在细胞损伤。除了关注细胞毒性（暴露于 SPION 导致的最常用的毒性决定因素）之外，本综述还提到了研究 DNA 损伤和氧化应激形式的微妙细胞变化的重要性。我们回顾了当前的研究，并讨论了 SPION（无论有或没有不同的表面涂层）如何引起细胞扰动，包括肌动蛋白细胞骨架的调节、基因表达谱的改变、铁稳态的紊乱和细胞反应的改变，例如信号通路的激活和细胞周期调节的损害。还讨论了蛋白质-SPION 相互作用的重要性以及与 SPION 暴露相关的各种安全考虑因素。
Superparamagnetic iron oxide nanoparticles (SPION) are being widely used for various biomedical applications, for example, magnetic resonance imaging, targeted delivery of drugs or genes, and in hyperthermia. Although, the potential benefits of SPION are considerable, there is a distinct need to identify any potential cellular damage associated with these nanoparticles. Besides focussing on cytotoxicity, the most commonly used determinant of toxicity as a result of exposure to SPION, this review also mentions the importance of studying the subtle cellular alterations in the form of DNA damage and oxidative stress. We review current studies and discuss how SPION, with or without different surface coating, may cause cellular perturbations including modulation of actin cytoskeleton, alteration in gene expression profiles, disturbance in iron homeostasis and altered cellular responses such as activation of signalling pathways and impairment of cell cycle regulation. The importance of protein-SPION interaction and various safety considerations relating to SPION exposure are also addressed.