The effects of repeated alcohol exposure on the neurochemistry of the periadolescent nucleus accumbens septi.
The effects of repeated alcohol exposure on the neurochemistry of the periadolescent nucleus accumbens septi.
复制标题
反复接触酒精对青春期伏隔核神经化学的影响。
DOI：
10.1097/00001756-199805110-00020
复制
发表时间：
1998
期刊：
影响因子：
1.7
通讯作者：
Kirstein,CL
中科院分区：
文献类型：
--
作者：
Philpot,RM;Kirstein,CL
药物滥用是当今社会的一个主要问题，也是青少年人口中一个至关重要的问题。研究表明，物质使用通常是在青少年时期开始的，而大脑的奖励区域在这个时期仍在发生变化。尽管如此，很少有研究调查反复使用药物对青春期周围动物奖励机制的影响。因此，本研究检测了重复乙醇（EtOH）给药对伏隔核（NAcc）对EtOH或生理盐水刺激的反应性的影响。数据表明，反复暴露于EtOH会导致NAcc多巴胺能（DAergic）活性的时间变化，活性峰值出现的时间提前。重要的是，在重复注射EtOH后，单独注射生理盐水会引起NAcc中DA的增加，这表明酒精摄入会对神经化学强化机制的反应方式产生根本性的变化。仅对药物的预期就会引起NAcc内与奖励相关的活动。
SUBSTANCE abuse is a major issue in today's society and is an issue of critical importance in the adolescent population. Research indicates that substance use is often initiated during the adolescent period and that brain reward areas are still undergoing changes during this time. Despite this, little research has investigated the effects of repeated drug use on the reward mechanisms of periadolescent animals. For this reason, the present study examined the effects of repeated ethanol (EtOH) administration on the responsiveness of the nucleus accumbens septi (NAcc) to either EtOH or saline challenge. The data indicate that repeated exposure to EtOH produces temporal shifts in the dopaminergic (DAergic) activity of the NAcc, with peak activity occurring earlier. Importantly, following repeated injections of EtOH, saline injections alone elicit DA increases in the NAcc suggesting that the context of alcohol administration produces fundamental changes in the way that neuro-chemical reinforcement mechanisms respond. The expectancy of the drug alone elicits reward-related activity within the NAcc.