Stochastic machines as a colocalization mechanism for scaffold protein function.
Stochastic machines as a colocalization mechanism for scaffold protein function.
复制标题
随机机器作为支架蛋白功能的共定位机制。
DOI：
10.1016/j.febslet.2013.04.006
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发表时间：
2013
期刊：
影响因子：
3.5
通讯作者：
Dunker,AKeith
中科院分区：
文献类型：
--
作者：
Xue,Bin;Romero,PedroR;Noutsou,Maria;Maurice,MadelonM;Rüdiger,StefanGD;WilliamJr,AlbertM;Mizianty,MarcinJ;Kurgan,Lukasz;Uversky,VladimirN;Dunker,AKeith
The axis inhibition (Axin) scaffold protein colocalizes β-catenin, casein kinase Iα, and glycogen synthetase kinase 3β by their binding to Axin’s long intrinsically disordered region, thereby yielding structured domains with flexible linkers. This complex leads to the phosphorylation of β-catenin, marking it for destruction. Fusing proteins with flexible linkers vastly accelerates chemical interactions between them by their colocalization. Here we propose that the complex works by random movements of a “stochastic machine,” not by coordinated conformational changes. This non-covalent, modular assembly process allows the various molecular machine components to be used in multiple processes.
