USE OF ANALGESICS AND RISK OF RENAL-CELL CANCER
USE OF ANALGESICS AND RISK OF RENAL-CELL CANCER
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DOI：
10.1002/ijc.2910590406
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发表时间：
1994-11-15
影响因子：
6.4
通讯作者：
MANDEL, JS
中科院分区：
文献类型：
--
作者：
CHOW, WH;MCLAUGHLIN, JK;MANDEL, JS
尽管多项研究表明大量或长期使用镇痛药与肾细胞癌的风险有关，但这种关联的证据仍不确定。在一项基于人群的病例对照研究中，包括 440 例肾细胞癌病例、另外 151 例病例的配偶和 691 例对照，我们评估了那些在面对面访谈中定期（每周至少 2 次或以上，持续 1 个月或更长时间）使用镇痛药的人与终生服用镇痛药相关的肾细胞癌风险。使用逻辑回归分析计算优势比（OR）。经常使用阿司匹林、对乙酰氨基酚、非那西丁或这些药物的组合不会导致额外的风险，而且这些镇痛药的累积摄入量增加也不会增加风险。在仅使用含对乙酰氨基酚的镇痛药的女性中观察到风险没有显着增加（OR = 2.1，95% CI = 0.6-6.9），但在男性中几乎没有发现过量。早期的研究报道了与含非那西丁的镇痛药的联系，但没有人报告在我们的研究中专门使用含非那西丁的药物。研究结果表明，镇痛药的使用不太可能在肾细胞癌的发展中发挥主要作用，并且对于 20 世纪 80 年代末或以后诊断的病例，在含有非那西丁的药物提前从市场上撤出后，这种镇痛药的危害不再存在。 (C) 1994 年 Wiley-Liss 公司
Although heavy or long-term use of analgesics has been related to risk of renal cell cancer in several studies, evidence for such an association remains inconclusive. In a population-based case-control study including 440 renal cell cancer cases, spouses of an additional 151 cases, and 691 controls, we assessed renal cell cancer risk associated with lifetime consumption among those who reported during in-person interviews regular (at least 2 or more times per week for I month or longer) use of analgesics. Odds ratios (OR) were computed using logistic regression analyses. No excess risk was associated with regular use of aspirin, acetaminophen, phenacetin or combinations of these agents, nor did risks rise with increasing cumulative intake of these analgesics. A non-significant increased risk (OR = 2.1, 95% CI = 0.6-6.9) was observed among women who used only acetaminophen-containing analgesics, but little excess was seen in men. Earlier studies reported a link to phenacetin-containing analgesics, but no one reported exclusive use of phenacetin-containing drugs in our study. The findings suggest that use of analgesics is not likely to play a major role in renal cell cancer development and that for cases diagnosed in the late 1980s or later, after the earlier withdrawal of phenacetin containing drugs from the market, a hazard from this analgesic no longer exists. (C) 1994 Wiley-Liss, Inc.