Reduction of potential respiratory pathogens by oral hygienic treatment in patients undergoing endotracheal anesthesia.
Reduction of potential respiratory pathogens by oral hygienic treatment in patients undergoing endotracheal anesthesia.
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DOI：
10.1007/s005400300022
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发表时间：
2003-01-01
影响因子：
2.8
通讯作者：
Okuda, Katsuji
中科院分区：
文献类型：
--
作者：
Okuda, Minori;Kaneko, Yuzuru;Okuda, Katsuji
目得：本研究进行了评估的有用性的机械和化学预防性口腔清洁治疗，以减少潜在的呼吸道病原体存在于oral cavity.METHODS：32例患者安排接受口腔颌面外科手术，需要气管内麻醉随机分配到两组之一，口腔清洁组（n = 16）或noncleansing组（n = 16）。培养和聚合酶链反应（PCR）方法用于检测和计数病原体。术前用能自动供应和抽吸聚维酮碘溶液的电动牙刷进行口腔清洁，术后每天冲洗两次。结果：患者漱口液中肺炎链球菌、流感嗜血杆菌、铜绿假单胞菌和牙龈卟啉单胞菌的PCR检出率分别为87.5%、68.8%、53.1%和40.6%。口腔清洁可降低甲氧西林敏感葡萄球菌的检出率和数量。pneumoniae和H.流感。与此相反，耐甲氧西林葡萄球菌（S。pneumoniae，H.流感，或铜绿假单胞菌在受试者谁经历了系统的头孢唑啉管理没有oral cleans.CONCLUSION：机械和化学口腔清洁的组合导致在口腔中的潜在呼吸道病原体的显着减少。
PURPOSE: This study was conducted to evaluate the usefulness of mechanical and chemical prophylactic oral cleansing treatments for reducing potential respiratory pathogens existing in the oral cavity.METHODS: Thirty-two patients scheduled to undergo oral and maxillofacial surgery that required endotracheal anesthesia were randomly allocated to one of the two groups, the oral cleansing group (n = 16) or the noncleansing group (n = 16). Culture and polymerase chain reaction (PCR) methods were used to detect and enumerate pathogens. Oral cleansing was carried out with an electric toothbrush capable of automatically supplying and aspirating povidone-iodine solution before surgery, followed by rinsing twice a day after surgery. Cephazolin (3 g x day(-1)) was given to all patients for 5 days after surgery.RESULTS: The PCR detection rates of Streptococcus pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa, and Porphyromonas gingivalis in gargle samples before treatment were 87.5%, 68.8%, 53.1%, and 40.6%, respectively. Oral cleansing reduced the detection rates and numbers of methicillin-sensitive Staphylococcus species, S. pneumoniae, and H. influenzae. In contrast, there was no significant reduction of methicillin-resistant Staphylococcus species, S. pneumoniae, H. influenzae, or P. aeruginosa in subjects who underwent systemic cephazolin administration without oral cleansing.CONCLUSION: The combination of mechanical and chemical oral cleansing resulted in a significant reduction of potential respiratory pathogens in the oral cavity.