Multifaceted roles of PGE2 in inflammation and cancer.
Multifaceted roles of PGE2 in inflammation and cancer.
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DOI：
10.1007/s00281-012-0342-8
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发表时间：
2013-03
影响因子：
9
通讯作者：
Rosenberg, Daniel W.
中科院分区：
文献类型：
--
作者：
Nakanishi, Masako;Rosenberg, Daniel W.
前列腺素E2（PGE 2）是一种生物活性脂质，可产生与炎症和癌症相关的广泛生物学效应。PGE 2在细胞增殖、凋亡、血管生成、炎症和免疫监视中发挥多种作用。这篇综述主要集中在胃肠道癌症，其中PGE 2的作用是最突出的，最有可能是由于不断暴露于饮食和环境的侮辱和内在的作用，PGE 2在组织内稳态。提供了对最近努力阐明将PGE 2信号传导与炎症和癌症联系起来的复杂和相互关联的途径的讨论，并得到了大量文献的支持，这些文献显示了NSAID的保护作用和靶向mPGES-1或EP受体预防癌症的治疗效果。然而，抑制PGE 2形成作为提供针对所有癌症的化学保护的手段可能最终是站不住脚的，无疑是炎症性肠病患者的情况。未来的研究将需要充分了解PGE 2在炎症和癌症中的复杂作用，以开发有效和安全的癌症预防新策略。
Prostaglandin E2 (PGE2) is a bioactive lipid that elicits a wide range of biological effects associated with inflammation and cancer. PGE2 exerts diverse effects on cell proliferation, apoptosis, angiogenesis, inflammation and immune surveillance. This review concentrates primarily on gastrointestinal cancers, where the actions of PGE2 are most prominent, most likely due to the constant exposure to dietary and environmental insults and the intrinsic role of PGE2 in tissue homeostasis. A discussion of recent efforts to elucidate the complex and interconnected pathways that link PGE2 signaling with inflammation and cancer is provided, supported by the abundant literature showing a protective effect of NSAIDs and the therapeutic efficacy of targeting mPGES-1 or EP receptors for cancer prevention. However, suppressing PGE2 formation as a means of providing chemoprotection against all cancers may not ultimately be tenable, undoubtedly the situation for patients with inflammatory bowel disease. Future studies to fully understand the complex role of PGE2 in both inflammation and cancer will be required to develop novel strategies for cancer prevention that are both effective and safe.
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