Incidence, survival and mortality rates of stage-specific bladder cancer in United States: A trend analysis
Incidence, survival and mortality rates of stage-specific bladder cancer in United States: A trend analysis
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DOI：
10.1016/j.canep.2013.02.002
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发表时间：
2013-06-01
影响因子：
2.6
通讯作者：
Sun, Maxine
中科院分区：
文献类型：
--
作者：
Abdollah, Firas;Gandaglia, Giorgio;Sun, Maxine
目的：研究1973年至2009年美国膀胱癌（BCa）的总体和分期年龄调整发病率、5年生存率和死亡率。材料和方法：1973年至2009年，在监测、流行病学和最终结果数据库中共确定了148，315例BCa患者。计算了发病率、死亡率和5年癌症特异性生存率。使用估计年度百分比变化（EAPC）和线性回归模型对时间趋势进行了量化。所有分析均根据疾病阶段进行分层，并根据性别，种族和年龄组进行进一步检查。结果：1973年至2009年期间，BCa的发病率从21.0/10万人年增加到25.5/10万人年。分期特异性分析显示，局限期的发生率增加：15.4 - 20.2（EAPC：+0.5%，p <0.001），远处期增加：0.5 - 0.8（EAPC：+0.7%，p = 0.001）。除远处疾病外，所有分期的分期特异性5年生存率均增加。在局限性（EAPC：-0.2%，p = 0.1）和区域性分期（EAPC：-0.1%，p = 0.5）中，死亡率无显著变化。在远处分期中观察到死亡率增加（EAPC：+1.0%，p = 0.005）。显着的变化，发病率和死亡率记录时，估计分层，根据性别，种族，和年龄groups.Discussion：Albeit统计学显着，几乎所有的变化，发病率和死亡率是轻微的，几乎没有任何临床意义。在研究期间，BCa癌症控制结果几乎没有变化。(C)2013爱思唯尔有限公司保留所有权利。
Purpose: To examine the overall and stage-specific age-adjusted incidence, 5-year survival and mortality rates of bladder cancer (BCa) in the United States, between 1973 and 2009.Materials and methods: A total of 148,315 BCa patients were identified in the Surveillance, Epidemiology and End Results database, between years 1973 and 2009. Incidence, mortality, and 5-year cancer-specific survival rates were calculated. Temporal trends were quantified using the estimated annual percentage change (EAPC) and linear regression models. All analyses were stratified according to disease stage, and further examined according to sex, race, and age groups.Results: Incidence rate of BCa increased from 21.0 to 25.5/100,000 person-years between 1973 and 2009. Stage-specific analyses revealed an increase incidence for localized stage: 15.4-20.2 (EAPC: +0.5%, p < 0.001) and distant stage: 0.5-0.8 (EAPC: +0.7%, p = 0.001). Stage-specific 5-year survival rates increased for all stages, except for distant disease. No significant changes in mortality were recorded among localized (EAPC: -0.2%, p = 0.1) and regional stage (EAPC: -0.1%, p = 0.5). An increase in mortality rates was observed among distant stage (EAPC: +1.0%, p = 0.005). Significant variations in incidence and mortality were recorded when estimates were stratified according to sex, race, and age groups.Discussion: Albeit statistically significant, virtually all changes in incidence and mortality were minor, and hardly of any clinical importance. Little or no change in BCa cancer control outcomes has been achieved during the study period. (C) 2013 Elsevier Ltd. All rights reserved.