The role of microRNAs in osteoclasts and osteoporosis.
The role of microRNAs in osteoclasts and osteoporosis.
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MicroRNA 在破骨细胞和骨质疏松症中的作用
DOI：
10.1080/15476286.2014.996462
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发表时间：
2014
期刊：
影响因子：
4.1
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Tang P;Xiong Q;Ge W;Zhang L
破骨细胞是骨吸收的唯一细胞。破骨细胞异常激活会导致骨密度低下，从而导致骨质减少、骨质疏松和其他骨骼疾病。迄今为止，破骨细胞前体如何分化为成熟破骨细胞的机制仍然难以捉摸。 MicroRNA (miRNA) 是一种新型调控因子，通过基因的转录后调控在细胞分化和凋亡等众多细胞过程中发挥重要作用。最近，许多研究表明miRNA参与骨稳态，包括破骨细胞骨吸收，这揭示了破骨细胞分化的机制。在这篇综述中，我们重点介绍了参与调节破骨细胞分化和骨吸收的 miRNA，及其在骨质疏松症中的作用。
Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone disorders. To date, the mechanism of how osteoclast precursors differentiate into mature osteoclasts remains elusive. MicroRNAs (miRNAs) are novel regulatory factors that play an important role in numerous cellular processes, including cell differentiation and apoptosis, by post-transcriptional regulation of genes. Recently, a number of studies have revealed that miRNAs participate in bone homeostasis, including osteoclastic bone resorption, which sheds light on the mechanisms underlying osteoclast differentiation. In this review, we highlight the miRNAs involved in regulating osteoclast differentiation and bone resorption, and their roles in osteoporosis.