Serum levels of TWEAK in patients with psoriasis vulgaris
Serum levels of TWEAK in patients with psoriasis vulgaris
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DOI：
10.1016/j.cyto.2015.10.004
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发表时间：
2016-01-01
期刊：
影响因子：
3.8
通讯作者：
Altinyazar, Cevdet
中科院分区：
文献类型：
--
作者：
Bilgic, Ozlem;Sivrikaya, Abdullah;Altinyazar, Cevdet
肿瘤坏死因子（TNF）样弱凋亡诱导因子（TWEAK）参与多种炎症性疾病和自身免疫性疾病的发病机制。然而，关于TWEAK与银屑病患者关系的研究有限。在这项研究中，我们的目的是探索TWEAK的血清水平，并调查TWEAK水平是否与临床变量和其他众所周知的银屑病相关细胞因子，包括IL-6，IL-23和TNF-α的表达相关。45例慢性斑块状银屑病患者和43名对照者参加了这项研究。银屑病的严重程度通过银屑病面积和严重程度指数（PASI）进行评估。使用商业酶联免疫吸附测定（ELISA）试剂盒测量血清细胞因子水平。银屑病患者的平均TWEAK、IL-6、IL-23和TNF-α水平显著高于对照组。而银屑病的严重程度、病程与血清细胞因子水平无明显相关性。这项研究表明，TWEAK可能与银屑病的发病机制有关，如TNF-α，IL-6和IL-23。(C)2015爱思唯尔有限公司版权所有。
Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) has been implicated in the pathogenesis of a variety of inflammatory disorders and autoimmune diseases. However, studies conducted on the relationship of TWEAK and psoriasis patients are limited. In this study, we aimed to explore the serum levels of TWEAK and investigated whether TWEAK levels are associated with clinical variables and expression of other well-known psoriasis-related cytokines including IL-6, IL-23 and TNF-alpha. Fortyfive patients with chronic plaque psoriasis and 43 controls were enrolled in this study. The severity of psoriasis was assessed by the Psoriasis Area and Severity Index (PASI). Serum levels of cytokines were measured using commercial enzyme-linked immunosorbent assay (ELISA) kits. The mean TWEAK, IL-6, IL-23, and TN-alpha levels were significantly higher in psoriasis patients than in control subjects. However, there were no significant correlations between the psoriasis severity, the illness duration and serum cytokine levels. This study shows that TWEAK may be associated with the pathogenesis of psoriasis, like TNF-alpha, IL-6, and IL-23. (C) 2015 Elsevier Ltd. All rights reserved.