APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age.
APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age.
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DOI：
10.3233/jad-201205
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Sebastiani P
中科院分区：
文献类型：
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作者：
Sweigart B;Andersen SL;Gurinovich A;Cosentino S;Schupf N;Perls TT;Sebastiani P
已知APOE基因的E4等位基因与认知障碍相关。然而，有限数量的研究已经检查了E2等位基因和认知功能的纵向变化之间的关联。确定与其他基因型相比，APOE E2等位基因携带者的认知变化率是否不同。我们对两项正在进行的纵向队列研究（长寿家庭研究（LLFS）和新英格兰百岁老人研究（NECS））的数据进行了二次分析。我们纳入了有APOE基因分型数据的参与者，来自认知状态电话访谈（TICS）纵向管理的数据，以及年龄，性别和教育程度。我们评估了不同APOE基因型人群中TICS评分下降率测量的认知变化是否存在差异。我们采用分层混合效应模型，包括APOE基因型、它们与年龄的相互作用以及潜在的混杂因素。在调整性别和教育后，常见E3/E3基因型携带者的TICS评分每年下降0.15分。在E2/E2基因型的患者中，TICS评分每岁下降0.05分，下降速度明显减慢（P=0.017）。我们没有观察到E2/E3基因型对认知能力下降的保护作用。这些结果表明E2/E2基因型对整体认知功能的测量具有保护作用。
The E4 allele of the APOE gene is known to be associated with cognitive impairment. However, a limited number of studies have examined the association between the E2 allele and longitudinal changes of cognitive function. To determine whether rates of cognitive change differ in carriers of the APOE E2 allele compared to other genotypes. We conducted a secondary analysis of data from two ongoing longitudinal cohort studies, the Long Life Family Study (LLFS) and New England Centenarian Study (NECS). We included participants who had APOE genotyping data, data from longitudinal administrations of the Telephone Interview for Cognitive Status (TICS), and age, sex and education available. We assessed whether cognitive change as measured by rate of decline in TICS score differed among people with different APOE genotypes. We used a hierarchical mixed effect model with APOE genotypes, their interactions with age, and potential confounders. After adjusting for sex and education, in carriers of the common E3/E3 genotype TICS score decreased by 0.15 points per year of age. In those with the E2/E2 genotype, TICS score decreased by 0.05 points per year of age, a significantly slower rate of decline (P=0.017). We observed no protective effect of the E2/E3 genotype on cognitive decline. These results suggest a protective effect of the E2/E2 genotype on a measure of global cognitive function.