Decreased cognitive function in extended family members from the single late-onset-Alzheimer's-disease pedigree.
Decreased cognitive function in extended family members from the single late-onset-Alzheimer's-disease pedigree.
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来自单一晚发性阿尔茨海默病谱系的大家庭成员的认知功能下降。
DOI：
10.1017/s1355617713000581
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发表时间：
2013-08
影响因子：
2.6
通讯作者：
McClintock, Shawn M.
中科院分区：
文献类型：
--
作者：
Zeng, Yan;Chang, Wei;Shu, Chang;Ma, Lina;Huang, Yuanyuan;Wang, Ruoshi;Zhang, Junpeng;Zhu, Changcai;McClintock, Shawn M.
痴呆症的家族史与老年痴呆症（AD）晚期（LOAD）的风险增加有关。本研究首次尝试在中国社区的一个大的以家庭为基础的群体中评估家庭对认知表现差异的贡献。我们从一个家系中招募了168名没有痴呆的参与者，其中9名可能的AD患者在65岁后被诊断出来。采用综合神经心理成套测验、简易精神状态检查量表中文版和阿尔茨海默病评定量表-认知分量表对这些受试者进行评估。分析发现，与对照组相比，LOAD家系的大家庭成员在整体认知功能和语义记忆方面表现出相似的表现，但在情景记忆、注意力和执行功能方面的得分较低。这些结果表明，尽管整体认知功能正常，但对某些亚认知领域的遗传影响更容易检测到，并且具有LOAD谱系的家庭成员由于其家族史而具有因年龄增加而增加的附加风险而具有发展LOAD的风险。这项研究的结果支持了在临床评估中记录AD家族史的重要性。
A family history of dementia is associated with an increased risk of developing Alzheimer’s disease (AD) late in life (LOAD). This study marked the first attempt to assess the familial contribution to differences in cognitive performance in a large family-based group in the Chinese community. We enrolled 168 participants without dementia from a single pedigree with 9 probable AD patients diagnosed after age 65. These participants were evaluated with a comprehensive neuropsychological battery, the Chinese version of the Mini Mental State Examination, and the Alzheimer Disease Assessment Scale–Cognitive Subscale. Analyses found that extended family members of the LOAD pedigree showed similar performance on measures of global cognitive function and semantic memory compared to controls, but lower scores on episodic memory, attention, and executive function measures. These results indicate that the genetic influences on certain sub-cognitive domains are more detectable despite normal global cognitive function, and that family members with the LOAD pedigree are at risk for developing LOAD by virtue of their family history with an additive risk due to increased age. The findings in this study support the importance of documenting if there is a positive family history of AD in clinical evaluations.