MINIMAL STRUCTURAL REQUIREMENTS FOR ADJUVANT ACTIVITY OF BACTERIAL PEPTIDOGLYCAN DERIVATIVES
MINIMAL STRUCTURAL REQUIREMENTS FOR ADJUVANT ACTIVITY OF BACTERIAL PEPTIDOGLYCAN DERIVATIVES
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DOI：
10.1016/0006-291x(74)90458-6
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发表时间：
1974-01-01
影响因子：
3.1
通讯作者：
LEDERER, E
中科院分区：
文献类型：
--
作者：
ELLOUZ, F;ADAM, A;LEDERER, E
我们最近发现，含有细菌肽多糖的中位二氨基甲酸单体亚单位，即二糖四肽N-乙酰氨基葡萄糖-N-乙酰基muramyl-L-alanyl-D-isoglutaminyl-meso-diaminopimelyl-D-alanine可以取代弗氏佐剂中全部被杀死的分枝杆菌。我们现在报道活性分子的进一步结构简化；天然的N-乙酰-胞浆三肽已被发现具有活性；已发现的最小的佐剂分子是由新浪等人合成的N-乙酰-胞浆二肽。
We have recently shown that the monomeric subunit of mesodiaminopimelic acid containing bacterial peptidoglycans, ie the disaccharide tetrapeptide N-acetyl glucosaminyl-N-acetyl muramyl-L-alanyl-D-isoglutaminyl-meso-diaminopimelyl-D-alanine can replace whole killed mycobacteria in Freund's adjuvant. We now report further structural simplifications of the active molecule; natural N-acetyl-muramyl-tripeptides have been found active; the smallest adjuvant molecule found is a synthetic N-acetyl muramyl-dipeptide prepared by Sinaÿ et al.(1).