Secreted Cyclic Di-GMP Induces Stalk Cell Differentiation in the Eukaryote Dictyostelium discoideum.
Secreted Cyclic Di-GMP Induces Stalk Cell Differentiation in the Eukaryote Dictyostelium discoideum.
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DOI：
10.1128/jb.00321-15
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发表时间：
2016-01-01
影响因子：
3.2
通讯作者：
Schaap P
中科院分区：
文献类型：
--
作者：
Chen ZH;Schaap P
环状二-GMP (c-di-GMP) 目前被认为是原核生物中使用最广泛的细胞内信号分子，但最近才发现其在真核生物中的作用。在社会性变形虫盘基网柄菌中，原核生物型二鸟苷酸环化酶产生的c-di-GMP可诱导茎细胞分化，从而形成带有孢子的子实体。在这篇综述中，我们总结了目前已知的控制盘基网柄菌主要生命周期转变的机制，并特别关注 c-di-GMP 在茎形成中的作用。茎细胞分化具有自噬细胞死亡的特征，这一过程也发生在高等真核生物中。我们讨论了 c-di-GMP 和另一种信号分子分化诱导因子 1 在体外自噬细胞死亡和体内茎形成中各自的作用。
Cyclic di-GMP (c-di-GMP) is currently recognized as the most widely used intracellular signal molecule in prokaryotes, but roles in eukaryotes were only recently discovered. In the social amoeba Dictyostelium discoideum, c-di-GMP, produced by a prokaryote-type diguanylate cyclase, induces the differentiation of stalk cells, thereby enabling the formation of spore-bearing fruiting bodies. In this review, we summarize the currently known mechanisms that control the major life cycle transitions of Dictyostelium and focus particularly on the role of c-di-GMP in stalk formation. Stalk cell differentiation has characteristics of autophagic cell death, a process that also occurs in higher eukaryotes. We discuss the respective roles of c-di-GMP and of another signal molecule, differentiation-inducing factor 1, in autophagic cell death in vitro and in stalk formation in vivo.