Neuromagnetic imaging of movement-related cortical oscillations in children and adults: Age predicts post-movement beta rebound
Neuromagnetic imaging of movement-related cortical oscillations in children and adults: Age predicts post-movement beta rebound
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DOI：
10.1016/j.neuroimage.2010.01.077
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发表时间：
2010-06-01
期刊：
影响因子：
5.7
通讯作者：
Snead, O. C.
中科院分区：
文献类型：
--
作者：
Gaetz, W.;MacDonald, M.;Snead, O. C.
我们测量了两组发育不同的儿童的视觉线索运动反应，并将这些反应与一组成年人进行了比较。我们假设，如果运动后β反弹(PMBR)依赖于发育敏感的过程，则PMBR将在成人中最大，而在执行基本运动任务的儿童中将随年龄递减。20名儿童(10名4-6岁的幼儿；10名11-13岁的青春期儿童)和10名成年人都在分别记录右手和左手食指的运动时记录到脑磁图。双侧感觉运动区的β频段(15-30赫兹)事件相关去同步化(ERD)被观察到从对侧和同侧MI随着年龄的增长而显著增加。运动相关的伽玛同步(60-90赫兹)也在各年龄组的对侧心肌梗死中观察到。然而，PMBR在4-6岁组显著减少，虽然更显著，但在青少年(11-13岁)组与成人组相比仍显著减少。PMBR测量在接受测试的最小儿童中很弱或不存在，在成人中表现为最大程度的双侧心肌梗死。因此，PMBR可能反映了初级运动皮质随年龄增长的抑制过程，这种抑制过程与正常发育有关。以前的研究表明，在成年参与者完成各种运动相关任务后，可能会从MI中观察到PMBR-然而，PMBR的来源和目的尚不清楚。目前的研究表明，从成年人身上观察到的来自MI的预期PMBR在青少年和幼儿中分别越来越小。儿童PMBR的减少可能反映了运动皮质抑制的减少。相对较少的运动抑制可能有利于神经元的可塑性，促进儿童的运动学习。(C)2010 Elsevier Inc.保留所有权利。
We measured visually-cued motor responses in two developmentally separate groups of children and compared these responses to a group of adults. We hypothesized that if post-movement beta rebound (PMBR) depends on developmentally sensitive processes, PMBR will be greatest in adults and progressively decrease in children performing a basic motor task as a function of age.Twenty children (10 young children 4-6 years; 10 adolescent children 11-13 years) and 10 adults all had MEG recorded during separate recordings of right and left index finger movements.Beta band (15-30 Hz) event-related desynchronization (ERD) of bi-lateral sensorimotor areas was observed to increase significantly from both contralateral and ipsilateral MI with age. Movement-related gamma synchrony (60-90 Hz) was also observed from contralateral MI for each age group. However, PMBR was significantly reduced in the 4-6 year group and, while more prominent, remained significantly diminished in the adolescent (11-13 year) age group as compared to adults. PMBR measures were weak or absent in the youngest children tested and appear maximally from bilateral MI in adults. Thus PMBR may reflect an age-dependent inhibitory process of the primary motor cortex which comes on-line with normal development.Previous studies have shown PMBR may be observed from MI following a variety of movement-related tasks in adult participants - however, the origin and purpose of the PMBR is unclear. The current study shows that the expected PMBR from MI observed from adults is increasingly diminished in adolescent and young children respectively. A reduction in PMBR from children may reflect reduced motor cortical inhibition. Relatively less motor inhibition may facilitate neuronal plasticity and promote motor learning in children. (C) 2010 Elsevier Inc. All rights reserved.