Balamuthia mandrillaris infection in China: a retrospective report of 28 cases.
Balamuthia mandrillaris infection in China: a retrospective report of 28 cases.
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中国山魈感染28例回顾性报告
DOI：
10.1080/22221751.2020.1835447
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发表时间：
2020-12
影响因子：
13.2
通讯作者：
Gao T
中科院分区：
文献类型：
--
作者：
Wang L;Cheng W;Li B;Jian Z;Qi X;Sun D;Gao J;Lu X;Yang Y;Lin K;Lu C;Chen J;Li C;Wang G;Gao T
扁桃体瘿蚊感染是一种罕见而致命的疾病。在过去的20年中，我们记录了28例扁桃体Balamuthia mandrillaris感染。18例患者（64%）为男性，10例（36%）为女性。患者年龄范围为3 - 74岁（平均27岁）。患者分布在中国12个省份。27例（96%）患者生活在农村地区，17例（61%）患者报告在皮肤病变出现之前有创伤史。所有病例均以皮肤损害为首发症状，16例（57%）发生脑炎。皮损组织学显示肉芽肿性改变，伴组织细胞、淋巴细胞和浆细胞浸润。所有病例均经免疫组化染色证实为阿米巴。27例（96%）病例提供了随访信息。15例（56%）患者死于脑炎，12例（44%）患者治疗后无疾病。我们的研究结果表明，在中国和美国的扁桃体Balamuthia mandrillaris感染的临床特征有很大不同。创伤皮肤感染可能在我国该病的发病机制中起重要作用。在中国病例中，脑炎通常在皮肤病变后3-4年发生。只有皮肤病变的患者治愈率高于脑炎患者。
Balamuthia mandrillaris infection is a rare and fatal disease. We have recorded 28 cases of Balamuthia mandrillaris infection during the past 20 years. Eighteen patients (64%) were male and 10 (36%) were female. Patient age ranged from 3 to 74 (mean, 27) years. Patient locations were distributed among 12 Provinces in China. Twenty-seven (96%) patients lived in rural areas, and 17 (61%) patients reported a history of trauma before the appearance of skin lesions. All cases presented with skin lesions as the primary symptom, and 16 (57%) cases developed encephalitis. Histopathology of skin lesions revealed granulomatous changes with histiocytes, lymphocytes, and plasma cells infiltration. Amebas were identified in all cases with immunohistochemical staining. Follow-up information was available in 27 (96%) cases. Fifteen (56%) patients died due to encephalitis and 12 (44%) were free of disease after treatment. Our results show that the clinical characteristics of Balamuthia mandrillaris infection in China are very different from those in the US. Infection of traumatized skin may play an important role in the pathogenesis of the disease in China. Encephalitis usually develops 3–4 years after skin lesions in Chinese cases. Patients with only skin lesions have a higher cure rate than patients with encephalitis.
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影响因子：
1.9
作者：
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通讯作者：
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