Positive relationship between total antioxidant status and chemokines observed in adults.
Positive relationship between total antioxidant status and chemokines observed in adults.
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在成人中观察到总抗氧化状态与趋化因子之间呈正相关。
DOI：
10.1155/2014/693680
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发表时间：
2014
影响因子：
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通讯作者：
Mu,Lina
中科院分区：
文献类型：
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作者：
Li,Yanli;Browne,RichardW;Bonner,MatthewR;Deng,Furong;Tian,Lili;Mu,Lina
Objective.关于氧化应激生物标志物和趋化因子之间相互作用的人类证据是有限的，特别是在没有明显临床疾病的成年人群体中。本研究旨在探讨成人抗氧化和脂质过氧化标记物与几种趋化因子的可能关系。我们评估了总抗氧化状态（TAS）和两种脂质过氧化标志物丙二醛（MDA）和硫代巴比妥酸反应物质（TBARS）与一系列血清趋化因子（包括CXCL-1（GRO-α）、CXCL-8（IL-8）、CXCL-10（IP-10）、CCL-2（MCP-1）、CCL-5（RANTES）、CCL-8（MCP-2）、CCL-11）的横断面相关性。（Eotaxin-1）和CCL-17（TARC）在2008年奥运会前北京104名无严重既往临床疾病的中国成年人中的表达。TAS与MCP-1（r= 0.15751，P = 0.0014）、MCP-2（r= 0.3721，P = 0.0001）、Eotaxin-1（r= 0.39598，P < 0.0001）和TARC（r= 0.27149，P = 0.0053）呈显著正相关。在控制了年龄、性别、体重指数、吸烟、饮酒等因素后，两者之间的正相关性保持不变。在本研究中测量的任何趋化因子与MDA或TBARS之间没有发现关联。当分析仅限于非吸烟者时，观察到类似的模式。总的抗氧化状态是正相关的几个趋化因子在这个成年人群体。
Objective. Human evidence is limited regarding the interaction between oxidative stress biomarkers and chemokines, especially in a population of adults without overt clinical disease. The current study aims to examine the possible relationships of antioxidant and lipid peroxidation markers with several chemokines in adults.Methods. We assessed cross‐sectional associations of total antioxidant status (TAS) and two lipid peroxidation markers malondialdehyde (MDA) and thiobarbituric acid reactive substances (TBARS) with a suite of serum chemokines, including CXCL‐1 (GRO‐α), CXCL‐8 (IL‐8), CXCL‐10 (IP‐10), CCL‐2 (MCP‐1), CCL‐5 (RANTES), CCL‐8 (MCP‐2), CCL‐11 (Eotaxin‐1), and CCL‐17 (TARC), among 104 Chinese adults without serious preexisting clinical conditions in Beijing before 2008 Olympics.Results. TAS showed significantly positive correlations with MCP‐1 (r= 0.15751,P= 0.0014), MCP‐2 (r= 0.3721,P= 0.0001), Eotaxin‐1 (r= 0.39598,P< 0.0001), and TARC (r= 0.27149,P= 0.0053). The positive correlations remained unchanged after controlling for age, sex, body mass index, smoking, and alcohol drinking status. No associations were found between any of the chemokines measured in this study and MDA or TBARS. Similar patterns were observed when the analyses were limited to nonsmokers.Conclusion. Total antioxidant status is positively associated with several chemokines in this adult population.