Adipose Tissue: A Safe Haven for Parasites?
Adipose Tissue: A Safe Haven for Parasites?
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DOI：
10.1016/j.pt.2016.11.008
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发表时间：
2017-04
影响因子：
9.6
通讯作者：
Figueiredo LM
中科院分区：
文献类型：
--
作者：
Tanowitz HB;Scherer PE;Mota MM;Figueiredo LM
脂肪组织（AT）不再被认为是一个惰性的脂质储存，而是作为一个重要的中央调节器的能量稳态和免疫。三种寄生虫物种在其生命周期的一部分期间与AT独特相关：克氏锥虫，恰加斯病的病原体，布氏锥虫，非洲昏睡病的原因和疟原虫属，疟疾的原因。在AT，T。cruzi存在于脂肪细胞内，T.布氏杆菌存在于脂肪细胞之间的间隙中，而疟原虫属（Plasmodium spp.）感染可能粘附在供应AT的血管上的红细胞。我们将讨论每种寄生虫如何适应这种组织环境，以及其对发病机制、临床表现和治疗的影响。
Adipose tissue (AT) is no longer regarded as an inert lipid storage, but as an important central regulator in energy homeostasis and in immunity. Three parasite species are uniquely associated with AT during part of their life cycle: Trypanosoma cruzi, the causative agent of Chagas disease, Trypanosoma brucei, the cause of African sleeping sickness and Plasmodium spp, the cause of malaria. In the AT, T. cruzi resides inside adipocytes, T. brucei is found in the interstitial spaces between adipocytes, while Plasmodium spp. infect red blood cells that may adhere to the blood vessels supplying AT. We will discuss how each parasite species adapts to this tissue environment and what the implications are for pathogenesis, clinical manifestations and therapy.