Medial prefrontal and subcortical mechanisms underlying the acquisition of motor and cognitive action sequences in humans
Medial prefrontal and subcortical mechanisms underlying the acquisition of motor and cognitive action sequences in humans
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DOI：
10.1016/s0896-6273(02)00742-0
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发表时间：
2002-07-18
期刊：
影响因子：
16.2
通讯作者：
Grafman, J
中科院分区：
文献类型：
--
作者：
Koechlin, E;Danek, A;Grafman, J
人类的前额叶皮层（AMPC）与情感和调节目标导向行为有关。然而，对AMPC的确切功能知之甚少。使用磁共振成像，我们发现，在AMPC的双边区域被选择性地招募，以计算受试者的期望，当受试者学习认知任务的序列时，开发的可靠性。与此相反，在腹侧纹状体中发现了在运动行为的学习序列中类似招募的区域。我们的研究结果表明，除了执行的运动行为，AMPC是有选择地参与计算的相关性的认知目标，受试者打算实现。这表明，额纹状体电路，包括腹侧纹状体和AMPC，subserves层次不同的评价过程介导的人类能力，建立行为计划，从运动到认知行动计划。
The anterior media[ prefrontal cortex (AMPC) in humans is involved in affect and in regulating goal-directed behaviors. The precise function of the AMPC, however, is poorly understood. Using magnetic resonance imaging, we found that bilateral regions in the AMPC were selectively recruited to compute the reliability of subjects' expectations that developed when subjects were learning sequences of cognitive tasks. In contrast, regions similarly recruited in learning sequences of motor acts were found in the ventral striatum. Our results show that beyond the execution of motor acts, the AMPC is selectively engaged in computing the relevance of cognitive goals that subjects intend to achieve. This indicates that the fronto-striatal circuit, including the ventral striatum and AMPC, subserves hierarchically distinct evaluative processes mediating the human ability to build behavioral plans, ranging from motor to cognitive action plans.