Strategies for tissue and organ decellularization
Strategies for tissue and organ decellularization
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DOI：
10.1002/jcb.24130
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发表时间：
2012-07-01
影响因子：
4
通讯作者：
Gilbert, Thomas W.
中科院分区：
文献类型：
--
作者：
Gilbert, Thomas W.
脱细胞组织已成功用于各种组织工程/再生医学应用，最近脱细胞器官已用于器官工程的第一阶段。用于使简单组织与完整器官脱细胞的方案差别很大。在本文中，描述了用于外科补片材料和整个器官的最常用的去细胞化方法，并考虑了这些不同的过程如何影响细胞外基质和宿主对支架的反应。J.细胞。113：2217222，2012中。(c)2012 Wiley Periodicals，Inc.
Decellularized tissues have been successfully used in a variety of tissue engineering/regenerative medicine applications, and more recently decellularized organs have been utilized in the first stages of organ engineering. The protocols used to decellularize simple tissues versus intact organs differ greatly. Herein, the most commonly used decellularization methods for both surgical mesh materials and whole organs are described, with consideration given to how these different processes affect the extracellular matrix and the host response to the scaffold. J. Cell. Biochem. 113: 22172222, 2012. (c) 2012 Wiley Periodicals, Inc.