Elastic sealants for surgical applications.
Elastic sealants for surgical applications.
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DOI：
10.1016/j.ejpb.2015.05.022
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Khademhosseini A
中科院分区：
文献类型：
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作者：
Annabi N;Yue K;Tamayol A;Khademhosseini A
密封剂已成为替代缝合线和斯台普斯的有希望的候选物，以防止手术期间和手术后的空气和液体泄漏。它们的物理性质和粘合强度密封伤口区域而不限制组织运动和功能是它们在临床实践中成功实施的关键因素。本文评述了合成和天然弹性密封材料的研究进展，并指出了其不足之处。此外，我们强调了密封剂的弹性至关重要的应用，并概述了目前可用的密封剂的局限性。这篇综述将为开发具有先进功能的新型生物粘合剂提供见解。
Sealants have emerged as promising candidates for replacing sutures and staples to prevent air and liquid leakages during and after the surgeries. Their physical properties and adhesion strength to seal the wound area without limiting the tissue movement and function are key factors in their successful implementation in clinical practice. In this contribution, the advances in the development of elastic sealants formed from synthetic and natural materials are critically reviewed and their shortcomings are pointed out. In addition, we highlight the applications in which elasticity of the sealant is critical and outline the limitations of the currently available sealants. This review will provide insights for the development of novel bioadhesives with advanced functionality for surgical applications.