Somatosensory mechanisms in zebrafish lacking dorsal root ganglia
Somatosensory mechanisms in zebrafish lacking dorsal root ganglia
复制标题
DOI：
10.1111/j.1469-7580.2010.01337.x
复制
发表时间：
2011-03-01
影响因子：
2.4
通讯作者：
Eisen, Judith S.
中科院分区：
文献类型：
--
作者：
Honjo, Yasuko;Payne, Laurel;Eisen, Judith S.
背根神经节（DRG）感觉神经元传递来自身体躯干区域的所有躯体感觉信息。erbb3突变斑马鱼不形成DRG神经元，因为产生它们的神经嵴细胞异常迁移。在这里，我们报告说，纯合子erbb3突变体似乎游泳和饲料正常，他们生存到成年，尽管从来没有形成DRG神经元。成人erbb3突变体感觉补偿的来源仍然未知，虽然它可能是从侧线神经节神经瘤减少，但目前，在erbb3突变体。我们还提供了新的信息，在野生型幼年斑马鱼背根神经节神经元的发展。
Dorsal root ganglion (DRG) sensory neurons transmit all somatosensory information from the trunk region of the body. erbb3 mutant zebrafish do not form DRG neurons because the neural crest cells that generate them migrate aberrantly. Here we report that homozygous erbb3 mutants appear to swim and feed normally, and that they survive through adulthood, despite never forming DRG neurons. The source of sensory compensation in adult erbb3 mutants remains unknown, although it may be from lateral line ganglion neuromasts which are reduced, but present, in erbb3 mutants. We also provide new information about the development of DRG neurons in wild-type juvenile zebrafish.