Population genomics: an investigative tool for epidemics.
Population genomics: an investigative tool for epidemics.
复制标题
群体基因组学：流行病调查工具。
DOI：
10.1016/j.ajpath.2012.01.007
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Bessen,DebraE
中科院分区：
文献类型：
--
作者：
Bessen,DebraE
Group A streptococcus (GAS) is a highly prevalent bacterial pathogen that has been recovered from its human hosts throughout the world. Most epidemiological studies characterize GAS isolates by their emm type, a molecular marker that has 200 distinct forms. The emm gene encodes M protein, a surface fibril that is a major virulence factor and target of protective immunity. Collection of GAS, along with the molecular typing of isolates, has been highly active throughout much of the world for the past several decades. Within any one community over a 1-or 2-year surveillance period, roughly 25 to 40 distinct emm types can be detected among the GAS isolates. 1–3 Each host community has a unique array of emm types, and the degree of overlap in the spectrum of emm types decreases for host populations in rough proportion to their geographical distance. Even within the same community, the predominating emm types can shift from year to year. 1
