Elevated norepinephrine may be an etiological factor in a wide range of diseases: Age-related macular degeneration, systemic lupus erythematosus, atrial fibrillation, metabolic syndrome
Elevated norepinephrine may be an etiological factor in a wide range of diseases: Age-related macular degeneration, systemic lupus erythematosus, atrial fibrillation, metabolic syndrome
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DOI：
10.1016/j.mehy.2013.01.018
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发表时间：
2013-05-01
影响因子：
4.7
通讯作者：
Fitzgerald, Paul J.
中科院分区：
文献类型：
--
作者：
Fitzgerald, Paul J.
神经递质去甲肾上腺素（NE）参与脑和外周中的广泛生理功能，其中它是交感神经系统的主要输出分子。NE受体存在于几乎所有（如果不是所有）身体器官中，这可能使该分子在各种疾病过程中发挥作用。本文研究了通过遗传和/或环境因素升高的NE信号传导是脑外多种疾病的病因因素的假设，包括年龄相关性黄斑变性、系统性红斑狼疮、心房颤动和代谢综合征。评估该假说的证据包括：（1）调节这四种疾病的去甲肾上腺素能药物的研究;（2）这些疾病与双相情感障碍、高血压和肥胖症的相关性，其中后三种疾病可能涉及NE信号的升高;（3）与心理应激的相关性，因为NE是对应激的反应。许多被引用的研究倾向于支持这一假设，或者至少与之相一致。如果这一假设是正确的，那么也许大量的人会从长期服用系统性减少去甲肾上腺素能信号的药物中受益，从而有助于预防或治疗各种疾病。(C)2013爱思唯尔有限公司保留所有权利。
The neurotransmitter norepinephrine (NE) participates in a broad range of physiological functions, both in the brain and in the periphery, where it is a principal output molecule of the sympathetic nervous system. NE receptors are present in nearly all, if not all, organs of the body, which may allow this molecule to play a role in a variety of disease processes. This paper examines the hypothesis elevated NE signaling, through genetics and/or environmental factors, is an etiological factor in a variety of diseases outside of the brain, including age-related macular degeneration, systemic lupus erythematosus, atrial fibrillation, and metabolic syndrome. Lines of evidence presented to assess the hypothesis include: (1) studies of noradrenergic drugs modulating the four diseases; (2) association of these diseases with bipolar disorder, hypertension, and obesity, where the latter three conditions may involve elevated NE signaling; and (3) association with psychological stress, since NE is released in response to stress. Many of the studies cited tend to support the hypothesis, or are at least consistent with it. If the hypothesis is correct, perhaps a large number of individuals would benefit from chronically taking drugs that systemically diminish noradrenergic signaling, thereby helping prevent or treat a wide variety of diseases. (C) 2013 Elsevier Ltd. All rights reserved.