Effects of amrinone, a cardiotonic drug, on calcium movements in dog erythrocytes.
Effects of amrinone, a cardiotonic drug, on calcium movements in dog erythrocytes.
复制标题
氨力农（一种强心药）对狗红细胞钙运动的影响。
DOI：
10.1172/jci109851
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Harper
中科院分区：
文献类型：
--
作者：
J. Parker;J. Harper
犬红细胞（RBC）具有被动Ca和Na运动系统，类似于首次在心肌中描述的Ca-Na交换器。氨力农是一种新的强心药，对充血性心力衰竭的人有活性，可刺激狗红细胞的净钙摄取。氨力农的作用是钙内流而不是外排。当细胞置于低钠介质中时，氨力农对Ca摄取的影响增强;升高外部Na或降低细胞内Na均取消药物的作用。这些数据表明，氨力农增强被动钙进入细胞的钠依赖性途径。如果钙通过心肌肌膜，就像通过狗的红细胞膜一样，那么氨力农的变力作用可以解释为该药物增加细胞内钙水平。
Dog erythrocytes (RBC) have a system for passive Ca and Na movements that resembles the Ca-Na exchanger first described in cardiac muscle. Amrinone, a new cardiotonic drug active in humans with congestive heart failure, is shown to stimulate net Ca uptake by dog RBC. Amrinone's action is on Ca influx rather than efflux. The influence of Amrinone on Ca uptake is enhanced when the cells are placed in low Na media; raising external Na or lowering intracellular Na both abolish the effect of the drug. The data suggest that amrinone potentiates passive Ca entry into the cells by a Na-dependent pathway. If Ca moves through myocardial sarcolemma as it does through dog RBC membranes, then the inotropic action of amrinone can be explained on the basis that the drug increases intracellular Ca levels.