Menstrual cyclic variation of myocardial ischemia in premenopausal women with variant angina
Menstrual cyclic variation of myocardial ischemia in premenopausal women with variant angina
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DOI：
10.7326/0003-4819-135-11-200112040-00009
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发表时间：
2001-12-04
影响因子：
39.2
通讯作者：
Yasue, H
中科院分区：
文献类型：
--
作者：
Kawano, H;Motoyama, T;Yasue, H
背景资料：大量的卵巢激素被认为是绝经前妇女缺血性心脏病发病率低的主要原因。然而，卵巢激素的影响仍然没有确定。目的：检查在月经周期中卵巢激素水平的变化是否会影响变异型心绞痛妇女的心肌缺血。设计：前瞻性，观察性研究。设置：日本大学医学中心。参与者：10名绝经前变异型心绞痛妇女。测量：自发性缺血发作的频率、血流介导的肱动脉扩张以及血清雌二醇和孕酮水平。缺血发作的频率从黄体期结束到月经期开始最高，卵泡期最低。流量介导的血管舒张和雌二醇水平最低，从黄体期结束到月经期开始，最高的卵泡phase.Conclusions：在绝经前妇女变异型心绞痛，我们记录了一个周期性的变化，内皮功能和心肌缺血的频率，与雌激素水平的变化。
Background: An abundance of ovarian hormones is assumed to be a major contributor to the low incidence of ischemic heart disease in premenopausal women. However, the effects of ovarian hormones remain undetermined.Objective: To examine whether the variation in ovarian hormone levels throughout a menstrual cycle affects myocardial ischemia in women with variant angina.Design: Prospective, observational study.Setting: University medical center in Japan.Participants: 10 premenopausal women with variant angina.Measurements: Frequency of spontaneous ischemic episodes, flow-mediated dilation of brachial artery, and serum levels of estradiol and progesterone.Results: Frequency of ischemic episodes was highest from the end of the luteal phase to the beginning of the menstrual phase and was lowest in the follicular phase. Flow-mediated vasodilation and estradiol levels were lowest from the end of the luteal phase to the beginning of the menstrual phase and were highest in the follicular phase.Conclusions: in premenopausal women with variant angina, we documented a cyclic variation in endothelial function and the frequency of myocardial ischemia that was associated with the variation in estrogen levels.