Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain
Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain
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DOI：
10.1126/science.290.5499.2140
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发表时间：
2000-12-15
期刊：
影响因子：
56.9
通讯作者：
Perlmann, T
中科院分区：
文献类型：
--
作者：
de Urquiza, AM;Liu, SY;Perlmann, T
类维生素A X受体（RXR）是一种核受体，作为配体激活的转录因子发挥作用。关于体内激活RXR的配体知之甚少。在这里，我们确定了成年小鼠脑组织中的一个因子，该因子在基于细胞的测定中激活RXR。通过质谱法对该因子进行纯化和分析，发现它是二十二碳六烯酸（DHA），一种高度富集于成年哺乳动物大脑中的长链多不饱和脂肪酸。以前的研究表明，DHA对大脑成熟至关重要，啮齿动物和人类缺乏DHA会导致空间学习受损和其他异常。这些数据表明，DHA可能通过激活RXR信号通路影响神经功能。
The retinoid X receptor (RXR) is a nuclear receptor that functions as a ligand-activated transcription factor. Little is known about the Ligands that activate RXR in vivo. Here, we identified a factor in brain tissue from adult mice that activates RXR in cell-based assays. Purification and analysis of the factor by mass spectrometry revealed that it is docosahexaenoic acid (DHA), a long-chain polyunsaturated fatty acid that is highly enriched in the adult mammalian brain. Previous work has shown that DHA is essential for brain maturation, and deficiency of DHA in both rodents and humans Leads to impaired spatial Learning and other abnormalities. These data suggest that DHA may influence neural function through activation of an RXR signaling pathway.