Essential roles for ecdysone signaling during Drosophila mid-embryonic development
Essential roles for ecdysone signaling during Drosophila mid-embryonic development
复制标题
DOI：
10.1126/science.1087419
复制
发表时间：
2003-09-26
期刊：
影响因子：
56.9
通讯作者：
Thummel, CS
中科院分区：
文献类型：
--
作者：
Kozlova, T;Thummel, CS
尽管类固醇激素蜕皮激素在果蝇变态过程中的功能已被很好地确定，但胚胎蜕皮激素脉冲的作用仍然知之甚少。我们发现，EcR-USP 蜕皮激素受体首先在胚胎外羊膜浆膜中被激活，表明该组织是早期胚胎中活性蜕皮激素的来源。胚带收缩和头部退化以及塑造第一龄幼虫的形态发生运动都需要蜕皮激素信号传导。这种在果蝇胚胎发育过程中协调形态发生的机制与蜕皮激素在变态过程中的作用相似。它还与哺乳动物胚胎外组织作为胚胎发育过程中类固醇激素的关键来源的作用提供了有趣的相似之处。
Although functions for the steroid hormone ecdysone during Drosophila metamorphosis have been well established, roles for the embryonic ecdysone pulse remain poorly understood. We show that the EcR-USP ecdysone receptor is first activated in the extraembryonic amnioserosa, implicating this tissue as a source of active ecdysteroids in the early embryo. Ecdysone signaling is required for germ band retraction and head involution, morphogenetic movements that shape the first instar larva. This mechanism for coordinating morphogenesis during Drosophila embryonic development parallels the role of ecdysone during metamorphosis. It also provides an intriguing parallel with the role of mammalian extraembryonic tissues as a critical source of steroid hormones during embryonic development.