G proteins in signal transduction.
G proteins in signal transduction.
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DOI：
10.1146/annurev.pa.30.040190.003331
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发表时间：
1990
影响因子：
12.5
通讯作者：
L. Birnbaumer
中科院分区：
文献类型：
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作者：
L. Birnbaumer
在过去的五年里，我们对G蛋白作为受体信号转化为效应器反应的转换器的中心和普遍作用的理解取得了重大进展，如图1所示。与其他GTP结合蛋白相反，信号转导G蛋白是由一个GTP结合（和水解）α亚基、一个β亚基和一个γ亚基形成的异源三聚体。知识的增长也许最好地说明了这一事实，
The last five years have seen major advances in our understanding of the central and generalized role of G-proteins as transducers of receptor signals into effector responses as outlined in Scheme 1. Signal-transducing G pro teins, in contrast to other GTP-binding proteins, are heterotrimers formed of one GTP-binding (and hydrolyzing) a subunit, one {3 subunit, and one 'Y subunit. I This increase in knowledge is perhaps best illustrated by the fact that