Triton channels are sensitive to divalent cations and protons
Triton channels are sensitive to divalent cations and protons
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Triton 通道对二价阳离子和质子敏感
DOI：
10.1007/bf00232876
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
C. Pasternak
中科院分区：
文献类型：
--
作者：
T. Rostovtseva;C. Bashford;A. Lev;C. Pasternak
将Triton X-100加入到由二酰磷脂酰胆碱、二酰磷脂酰胆碱或单酰甘油组成的平面双分子层中，在测量双分子层的电导率时可诱导单通道样事件。二价阳离子或质子的加入使通道消失；其余通道的单通道电导没有明显改变；EDTA或碱（分别）的加入则相反。结论是，对二价阳离子和质子的敏感性不需要依赖于特定的通道蛋白或成孔毒素，而可能是脂质环境中任何水孔的特征。
Addition of Triton X-100 to planar bilayers composed of dioleoyl phosphatidyl choline, diphytanoyl phosphatidyl choline or mono-oleoyl glycerol induces single channel-like events when electrical conductivity across the bilayer is measured. Addition of divalent cations or protons causes channels to disappear; single channel conductance of remaining channels is not significantly altered; addition of EDTA or alkali (respectively) reverses the effect. It is concluded that sensitivity to divalent cations and protons need not be dependent on specific channel proteins or pore-forming toxins, but may be a feature of any aqueous pore across a lipid milieu.
与细胞毒性 T 细胞颗粒相关的功能通道形成。
DOI：
10.1073/pnas.83.1.150
发表时间：
1986
影响因子：
11.1
作者：
Young,JD;Nathan,CF;Podack,ER;Palladino,MA;Cohn,ZA
通讯作者：
Cohn,ZA