Cognitive deficits in patients with a chronic vestibular failure
Cognitive deficits in patients with a chronic vestibular failure
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DOI：
10.1007/s00415-016-8386-7
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发表时间：
2017-03-01
影响因子：
6
通讯作者：
Dieterich, Marianne
中科院分区：
文献类型：
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作者：
Popp, Pauline;Wulff, Melanie;Dieterich, Marianne
对啮齿动物和人类的行为研究表明，双侧前庭衰竭 (BVF) 患者存在空间记忆和定向缺陷。我们的目的是探索慢性前庭功能障碍对不同认知领域（包括空间和非空间认知能力）的功能影响。 16 名单侧前庭衰竭 (UVF) 患者、18 名 BVF 患者和 17 名健康对照 (HC) 参与了该研究。为了评估短期记忆、执行功能、处理速度和视觉空间能力的认知领域，使用了以下测试：视觉注意力理论 (TVA)、TAP 警觉性和视觉扫描、Stroop 颜色词和 Corsi 块敲击测试。认知评分分别与前庭功能障碍程度和疾病持续时间相关。各组在年龄、性别或惯用手方面没有显着差异。 BVF 患者在所有检查的认知领域均显着受损，但并非在特定领域的所有测试中均显着受损，而 UVF 患者与 HC 独立比较时，其视觉空间能力和两项处理速度任务之一表现出显着受损。前庭功能障碍的程度与一些认知评分显着相关。病变的一侧和疾病的持续时间都不影响认知能力。结果表明，前庭功能障碍可能导致认知障碍，超出了前面描述的空间导航缺陷。这些认知障碍在 BVF 患者中更为明显，表明来自一侧迷路的输入分配到双侧前庭回路足以维持大部分认知功能。这些结果提出了一个问题：除了物理治疗之外，BVF 患者是否还可以从特定的认知训练中获益。
Behavioral studies in rodents and humans have demonstrated deficits of spatial memory and orientation in bilateral vestibular failure (BVF). Our aim was to explore the functional consequences of chronic vestibular failure on different cognitive domains including spatial as well as non-spatial cognitive abilities. Sixteen patients with a unilateral vestibular failure (UVF), 18 patients with a BVF, and 17 healthy controls (HC) participated in the study. To assess the cognitive domains of short-term memory, executive function, processing speed and visuospatial abilities the following tests were used: Theory of Visual Attention (TVA), TAP Alertness and Visual Scanning, the Stroop Color-Word, and the Corsi Block Tapping Test. The cognitive scores were correlated with the degree of vestibular dysfunction and the duration of the disease, respectively. Groups did not differ significantly in age, sex, or handedness. BVF patients were significantly impaired in all of the examined cognitive domains but not in all tests of the particular domain, whereas UVF patients exhibited significant impairments in their visuospatial abilities and in one of the two processing speed tasks when compared independently with HC. The degree of vestibular dysfunction significantly correlated with some of the cognitive scores. Neither the side of the lesion nor the duration of disease influenced cognitive performance. The results demonstrate that vestibular failure can lead to cognitive impairments beyond the spatial navigation deficits described earlier. These cognitive impairments are more significant in BVF patients, suggesting that the input from one labyrinth which is distributed into bilateral vestibular circuits is sufficient to maintain most of the cognitive functions. These results raise the question whether BVF patients may profit from specific cognitive training in addition to physiotherapy.