Exercising engineered heart muscle to maturity.
Exercising engineered heart muscle to maturity.
复制标题
锻炼工程心肌直至成熟。
DOI：
10.1038/s41569-018-0032-x
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Pu,WilliamT
中科院分区：
文献类型：
--
作者：
Zhang,Donghui;Pu,WilliamT
干细胞衍生的心肌细胞的不成熟阻碍了它们用于体外疾病建模、心脏毒性测定和细胞替代疗法。Ronaldson-Bouchard及其同事报道了干细胞衍生的心肌细胞的体外成熟。这一进展有望释放这些细胞的翻译潜力。
The immaturity of stem cell-derived cardiomyocytes has impeded their use for in vitro disease modelling, cardiotoxicity assays, and cell-replacement therapy. Ronaldson-Bouchard and colleagues report unparalleled in vitro maturation of stem cell-derived cardiomyocytes. This advance promises to unlock the translational potential of these cells.