PATTERNS OF ORGANIZATION OF ACTIN AND MYOSIN IN NORMAL AND TRANSFORMED CULTURED-CELLS
PATTERNS OF ORGANIZATION OF ACTIN AND MYOSIN IN NORMAL AND TRANSFORMED CULTURED-CELLS
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DOI：
10.1073/pnas.72.3.994
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发表时间：
1975-01-01
影响因子：
11.1
通讯作者：
WEBER, K
中科院分区：
文献类型：
--
作者：
POLLACK, R;OSBORN, M;WEBER, K
细胞内肌动蛋白和肌球蛋白的分布模式进行了检查，在一系列的正常，猿猴病毒-40-转化，和回复突变体细胞系的大鼠和小鼠起源的特异性免疫荧光。一个一致的相关性之间的敏感性锚定依赖的生长控制和存在的大，厚鞘的肌动蛋白含材料。这些鞘的存在是温度依赖性的大鼠线转化的致癌病毒猿猴病毒40的互补组A中的温度敏感的突变体。
The patterns of distribution of intracellular actin and myosin were examined by specific immunofluorescence in a series of normal, simian-virus-40-transformed, and revertant cell lines of rat and mouse origin. A consistent correlation was found between sensitivity to anchorage-dependent growth control and the presence of large, thick sheaths of actin-containing material. The presence of these sheaths was temperature-dependent in a rat line transformed by a temperature-sensitive mutant in the complementation group A of the oncogenic virus simian virus 40.