IRESdb:: the internal ribosome entry site database
IRESdb:: the internal ribosome entry site database
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DOI：
10.1093/nar/gkg003
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Vagner, S
中科院分区：
文献类型：
--
作者：
Bonnal, S;Boutonnet, C;Vagner, S
内部核糖体进入位点（Internal Ribosome Entry Sites，IRES）是一种顺式作用的RNA序列，能够介导40 S核糖体亚基进入某些真核生物和病毒信使RNA翻译起始密码子上游的内部。这些序列是非常多样的，并存在于越来越多的mRNA列表中。每年都有新的IRES序列被添加到公共数据库中，未知IRES的列表肯定仍然很大。IRES数据库是内部核糖体进入位点的综合性WWW资源，并提供当前可用的一般信息以及每个IRES的详细数据。它是可搜索的，定期更新的IRES RNA序列集合。序列以FASTA形式呈现并热链接到NCBI GenBank文件。根据病毒分类单位（对于病毒IRES）、基因产物功能（对于细胞IRES）、可能的细胞调节或介导IRES功能的反式作用因子，对几个数据子集进行分类。该数据库可在http：/ /ifr 31 w3上查阅。图卢兹。插入fr/IRES数据库/。
Internal Ribosome Entry Sites ( IRES) are cis - acting RNA sequences able to mediate internal entry of the 40S ribosomal subunit on some eukaryotic and viral messenger RNAs upstream of translation initiation codon. These sequences are very diverse and are present in growing list of mRNAs. Novel IRES sequences continue to be added to public databases every year and the list of unknown IRESes is certainly still very large. The IRES database is comprehensive WWW resource for internal ribosome entry sites and presents currently available general information as well as detailed data for each IRES. It is searchable, periodically updated collection of IRES RNA sequences. Sequences are presented in FASTA form and hotlinked to NCBI GenBank files. Several subsets of data are classified according to the viral taxon ( for viral IRESes), to the gene product function ( for cellular IRESes), to the possible cellular regulation or to the trans - acting factor that mediates IRES function. This database is accessible at http: / / ifr31w3. toulouse. inserm. fr/ IRESdatabase/.