Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface.
Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface.
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DOI：
10.1042/bst20210343
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发表时间：
2021-11-01
影响因子：
3.9
通讯作者：
Scott CJ
中科院分区：
文献类型：
--
作者：
Tracey SR;Smyth P;Barelle CJ;Scott CJ
在过去的二十年里，人们对纳米医学的兴趣迅速增长，这是由于它们可能提供的有希望的治疗应用，特别是用于治疗癌症。个性化药物和“智能”主动靶向纳米颗粒代表了将治疗直接递送到癌细胞并提供持续药物释放的机会，从而提供整体较低的脱靶毒性和增加的治疗效果。然而，迄今为止，纳米医学从令人鼓舞的临床前发现到临床的成功转化被证明是艰巨的。在这篇综述中，我们将讨论使用纳米药物治疗癌症，特别关注使用聚合物和脂质纳米颗粒递送系统。特别是，我们研究了探索纳米药物表面功能化的方法，以引起主动靶向和治疗效果，以及纳米颗粒在癌症治疗中的挑战和未来方向。
Interest in nanomedicines has grown rapidly over the past two decades, owing to the promising therapeutic applications they may provide, particularly for the treatment of cancer. Personalised medicine and ‘smart’ actively targeted nanoparticles represent an opportunity to deliver therapies directly to cancer cells and provide sustained drug release, in turn providing overall lower off-target toxicity and increased therapeutic efficacy. However, the successful translation of nanomedicines from encouraging pre-clinical findings to the clinic has, to date, proven arduous. In this review, we will discuss the use of nanomedicines for the treatment of cancer, with a specific focus on the use of polymeric and lipid nanoparticle delivery systems. In particular, we examine approaches exploring the surface functionalisation of nanomedicines to elicit active targeting and therapeutic effects as well as challenges and future directions for nanoparticles in cancer treatment.