Epidemiology of hepatocellular carcinoma in Hispanics in the United States
Epidemiology of hepatocellular carcinoma in Hispanics in the United States
复制标题
DOI：
10.1001/archinte.167.18.1983
复制
发表时间：
2007-10-08
影响因子：
--
通讯作者：
Goodwin, James
中科院分区：
文献类型：
--
作者：
El-Serag, Hashem B.;Lau, Melvin;Goodwin, James
背景资料：据我们所知，没有详细的分析存在肝细胞癌（HCC）的发病率和死亡率在西班牙裔美国人。在以前的研究中，西班牙裔的发病率没有单独报告从其他种族或ethnic groups.Methods：我们使用的信息诊断为肝癌的患者从13个登记处的监测流行病学和最终结果（SEER）数据库的国家癌症研究所计算种族特异性，年龄调整的发病率（AIR）在1992年和2002年之间。我们还使用了1979年至2001年之间的加州和德克萨斯州的死亡记录来计算种族特异性的、年龄调整的肝癌死亡率，不包括肝内胆管癌。对于西班牙裔和亚洲人/太平洋岛民，分别计算本地出生受试者和移民的患病率。在SEER中，西班牙裔美国人的年AIR比黑人高1.2倍（6.3 vs 5.0/100 000人-年的美国基础人群），比非西班牙裔白人高2.7倍（2.4/100 000人年），但低于亚洲人/太平洋岛民（10.8/100 000人年）。西班牙裔患者诊断为HCC时的中位年龄（64岁）介于白人（最年长）和黑人（最年轻）之间。在1992-1995年和2000-2002年期间，西班牙裔男性的HCC发病率增加了31%，西班牙裔女性增加了63%。种族特异性、年龄调整的死亡率在加州和德克萨斯州非常相似，亚洲/太平洋岛民移民的死亡率最高，其次是西班牙裔。本地西班牙裔男性的发病率是移民西班牙裔男性的两倍多。对于得克萨斯州，本地西班牙裔男性的发病率为65%，高于那些移民西班牙裔mesen.Conclusion：西班牙裔在美国有肝癌的发病率高，仅次于亚洲人/太平洋岛民。
Background: To our knowledge, no detailed analysis exists of the incidence and mortality of hepatocellular carcinoma (HCC) among Hispanics in the United States. In previous studies, the rates for Hispanics have not been reported separately from other racial or ethnic groups.Methods: We used information on patients diagnosed as having HCC from 13 registries in the Surveillance Epidemiology and End Results (SEER) database of the National Cancer Institute to calculate race-specific, age-adjusted incidence rates (AIR) between 1992 and 2002. We also used California and Texas state death records from between 1979 and 2001 to calculate race-specific, age-adjusted mortality rates for liver cancer excluding intrahepatic cholangiocarcinoma. For Hispanics and Asians/ Pacific Islanders, the rates were calculated for native-born subjects and immigrants separately.Results: In SEER, the yearly AIRs were higher by 1.2-fold in Hispanics than in blacks (6.3 vs 5.0 per 100 000 person-years of the underlying US population) and by 2.7-fold than in non-Hispanic whites (2.4 per 100 000 person-years) but lower than in Asians/Pacific Islanders (10.8 per 100 000 person-years). The median age at HCC diagnosis in Hispanics (64 years) was intermediate between whites (the oldest) and blacks (the youngest). Between the periods 1992-1995 and 2000-2002, there was a 31% increase in the incidence of HCC in Hispanic men and a 63% increase in Hispanic women. The race-specific, age-adjusted mortality rates were remarkably similar in California and Texas and were highest in immigrant Asian/Pacific Islanders followed by native Hispanics. The rates for native Hispanic men were more than twice as high as those for immigrant Hispanic men. For Texas, the rates for native Hispanic men were 65% higher than those for immigrant Hispanic men.Conclusion: Hispanics in the United States have high rates of HCC that are second only to Asians/Pacific Islanders.