COCAINE RECEPTORS ON DOPAMINE TRANSPORTERS ARE RELATED TO SELF-ADMINISTRATION OF COCAINE
COCAINE RECEPTORS ON DOPAMINE TRANSPORTERS ARE RELATED TO SELF-ADMINISTRATION OF COCAINE
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DOI：
10.1126/science.2820058
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发表时间：
1987-09-04
期刊：
影响因子：
56.9
通讯作者：
KUHAR, MJ
中科院分区：
文献类型：
--
作者：
RITZ, MC;LAMB, RJ;KUHAR, MJ
尽管可卡因与大脑中的几个部位结合，但与其依赖性产生特性相关的生化受体机制或机制尚不清楚。这里表明，可卡因样药物在自我管理研究的效力与它们的效力在抑制[3H]马吲哚结合到多巴胺转运体在大鼠纹状体，但不与它们的效力结合到大量的其他突触前和突触后结合位点。因此，与药物滥用相关的可卡因受体被认为是与多巴胺摄取抑制相关的受体。
Although cocaine binds to several sites in the brain, the biochemical receptor mechanism or mechanisms associated with its dependence producing properties are unknown. It is shown here that the potencies of cocaine-like drugs in self-administration studies correlate with their potencies in inhibiting [3H]mazindol binding to the dopamine transporters in the rat striatum, but not with their potencies in binding to a large number of other presynaptic and postsynaptic binding sites. Thus, the cocaine receptor related to substance abuse is proposed to be the one associated with dopamine uptake inhibition.