Reduced Amplitude of Low-Frequency Brain Oscillations in the Psychosis Risk Syndrome and Early Illness Schizophrenia
Reduced Amplitude of Low-Frequency Brain Oscillations in the Psychosis Risk Syndrome and Early Illness Schizophrenia
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DOI：
10.1038/npp.2016.51
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发表时间：
2016-08-01
影响因子：
7.6
通讯作者：
Mathalon, Daniel H.
中科院分区：
文献类型：
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作者：
Fryer, Susanna L.;Roach, Brian J.;Mathalon, Daniel H.
血氧水平依赖性（BOLD）信号的低频振荡（LFOs）作为神经精神病理敏感的潜在生物标志物越来越受到关注。精神分裂症与内在LFOs的改变有关，这种改变与认知缺陷和症状相关。然而，在精神分裂症发病前LFO功能障碍存在的程度尚不清楚。静息状态FMRI数据收集自12-35岁的临床高危青年（CHR, n = 45）、早期精神分裂症（ESZ, n = 74）患者和健康对照（hc, n = 85）。比较三组BOLD信号经年龄调整的低频波动体向分数幅值（fALFF; 0.01 ~ 0.08 Hz）。组内主要效果(p
Low-frequency oscillations (LFOs) of the blood oxygen level-dependent (BOLD) signal are gaining interest as potential biomarkers sensitive to neuropsychiatric pathology. Schizophrenia has been associated with alterations in intrinsic LFOs that covary with cognitive deficits and symptoms. However, the extent to which LFO dysfunction is present before schizophrenia illness onset remains unknown. Resting-state FMRI data were collected from clinical high-risk (CHR; n = 45) youth, early illness schizophrenia (ESZ; n = 74) patients, and healthy controls (HCs; n = 85) aged 12-35 years. Age-adjusted voxelwise fractional amplitude of low-frequency fluctuations (fALFF; 0.01 - 0.08 Hz) of the BOLD signal was compared among the three groups. Main effects of Group (p